False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies

L. Joseph Wheat, P. Connolly, M. Durkin, B. K. Book, A. J. Tector, J. Fridell, M. D. Pescovitz

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

False-positive Histoplasma antigen results were identified in two patients who received rabbit antithymocyte globulin (ATG, Thymoglobulin®) to prevent allograft rejection. To determine the prevalence of false-positive results following the administration of Thymoglobulin®, sequential specimens were tested from a cohort of transplant recipients. Of 107 such patients, 17 (15.9%) demonstrated false-positive tests for Histoplasma antigenemia. False antigenemia peaked at 2-4 weeks after ATG administration and cleared over the next few months. Physicians should be aware of the potential for false-positive results in specimens from patients who have received ATG.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalTransplant Infectious Disease
Volume6
Issue number1
DOIs
StatePublished - Mar 2004
Externally publishedYes

Keywords

  • Antigenemia
  • Antithymocyte globulin
  • False-positive
  • HARA
  • Histoplasmosis
  • Transplant

ASJC Scopus subject areas

  • Infectious Diseases
  • Transplantation

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