TY - JOUR
T1 - Failure to interrupt established pregnancy in humans by D-tryptophan-6-luteinizing hormone-releasing hormone
AU - Tolis, G.
AU - Comaru Schally, A. M.
AU - Mehta, A. E.
AU - Schally, A. V.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Four women 5 to 8 weeks into pregnancy, scheduled for therapeutic abortions, were given an analog of gonadotropin-releasing hormone, D-tryptophan-6-LHRH, in an effort to interrupt pregnancy. The treatment consisted of 100 μg injections, given twice daily for 5 to 10 days. No decline in serum β-hCG or progesterone was noted, and menstrual extraction was needed in all women for pregnancy interruption. These data indicate that D-Trp-6-LHRH is not effective as an abortifacient in established pregnancy.
AB - Four women 5 to 8 weeks into pregnancy, scheduled for therapeutic abortions, were given an analog of gonadotropin-releasing hormone, D-tryptophan-6-LHRH, in an effort to interrupt pregnancy. The treatment consisted of 100 μg injections, given twice daily for 5 to 10 days. No decline in serum β-hCG or progesterone was noted, and menstrual extraction was needed in all women for pregnancy interruption. These data indicate that D-Trp-6-LHRH is not effective as an abortifacient in established pregnancy.
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U2 - 10.1016/S0015-0282(16)45688-8
DO - 10.1016/S0015-0282(16)45688-8
M3 - Article
C2 - 6455307
AN - SCOPUS:0019439419
VL - 36
SP - 241
EP - 242
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 2
ER -