Failure to detect missense mutations in the S182 gene in a series of late-onset Alzheimer's disease cases

T. Tsuda, H. Chi, Y. Liang, E. A. Rogaeva, R. Sherrington, G. Levesque, M. Ikeda, E. I. Rogaev, D. Pollen, M. Freedman, R. Duara, P. H. St. George-Hyslop

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The possibility of an interaction of multiple genes has been speculated in pathogenesis of Alzheimer's disease (AD). Because we have recently cloned a novel gene S182 bearing five different missense mutations which segregate with early-onset familial AD, we sought the frequency of these mutations in familial and sporadic late-onset AD to clarify the incidence of these mutations in the disease. The current study showed lack of these mutations in 118 independent subjects affected with late-onset Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)188-190
Number of pages3
JournalNeuroscience Letters
Volume201
Issue number2
DOIs
StatePublished - Dec 8 1995

Keywords

  • Late-onset Alzheimer's disease
  • Missense mutation
  • S182 gene

ASJC Scopus subject areas

  • Neuroscience(all)

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