Failure to confirm a vascular cause of muscular dystrophy

Walter G Bradley, M. D. O'Brien, D. N. Walder, D. Murchison, M. Johnson, D. J. Newell

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The vascular hypothesis of the cause of muscular dystrophy suggests that ischemia is responsible for the muscle fiber necrosis. A xenon 133 clearance study of muscle blood flow in Duchenne and other muscular dystrophies showed no obvious difference between the response to exercise and arterial occlusion compared with control subjects. Radioautographic study of distribution of 4 125l antipyrine in skeletal muscle of mice with muscular dystrophy showed no abnormal areas of ischemia. A statistical examination was also made of the grouping of damaged fibers, one of the observations on which the vascular hypothesis was based. Only 0.9% of fibers undergoing phagocytosis occurred in groups of four or more fibers in greater frequency than would have been expected by chance, and 70% of such fibers were isolated. These studies argue strongly against the vascular hypothesis of the cause of muscular dystrophy.

Original languageEnglish
Pages (from-to)466-473
Number of pages8
JournalArchives of Neurology
Volume32
Issue number7
StatePublished - Dec 1 1975
Externally publishedYes

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Muscular Dystrophies
Blood Vessels
Ischemia
Antipyrine
Muscles
Xenon
Duchenne Muscular Dystrophy
Phagocytosis
Skeletal Muscle
Necrosis
Causes
Fiber

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bradley, W. G., O'Brien, M. D., Walder, D. N., Murchison, D., Johnson, M., & Newell, D. J. (1975). Failure to confirm a vascular cause of muscular dystrophy. Archives of Neurology, 32(7), 466-473.

Failure to confirm a vascular cause of muscular dystrophy. / Bradley, Walter G; O'Brien, M. D.; Walder, D. N.; Murchison, D.; Johnson, M.; Newell, D. J.

In: Archives of Neurology, Vol. 32, No. 7, 01.12.1975, p. 466-473.

Research output: Contribution to journalArticle

Bradley, WG, O'Brien, MD, Walder, DN, Murchison, D, Johnson, M & Newell, DJ 1975, 'Failure to confirm a vascular cause of muscular dystrophy', Archives of Neurology, vol. 32, no. 7, pp. 466-473.
Bradley WG, O'Brien MD, Walder DN, Murchison D, Johnson M, Newell DJ. Failure to confirm a vascular cause of muscular dystrophy. Archives of Neurology. 1975 Dec 1;32(7):466-473.
Bradley, Walter G ; O'Brien, M. D. ; Walder, D. N. ; Murchison, D. ; Johnson, M. ; Newell, D. J. / Failure to confirm a vascular cause of muscular dystrophy. In: Archives of Neurology. 1975 ; Vol. 32, No. 7. pp. 466-473.
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