Failure of Pure 1-Naphthylamine to Induce Bladder Tumors in Dogs

Jack L. Radomski, W. B. Deichmann, Norman H. Altman, Teresa Radomski

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

1-Naphthylamine was administered p.o. to beagles for approximately 9 years at a daily dose of 15 mg/kg (5 days a week). At autopsy, no tumors or other pathological changes were observed in bladders of any of these animals. With the possible exception of the excessive accumulation of lipofuscin in the hepatocytes of these dogs, no test compound-related pathological changes in other tissues of the body were observed. Analysis of the urine revealed the presence of small amounts of N-oxidation products (1-nitrosonaphthalene plus N-hydroxy-1-naphthylamine). ranging from 2.85 to 125 μg, following a dose of 1-naphthylamine. The theoretical significance of these findings is discussed.

Original languageEnglish (US)
Pages (from-to)3537-3539
Number of pages3
JournalCancer Research
Volume40
Issue number10
StatePublished - Oct 1 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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