1-Naphthylamine was administered p.o. to beagles for approximately 9 years at a daily dose of 15 mg/kg (5 days a week). At autopsy, no tumors or other pathological changes were observed in bladders of any of these animals. With the possible exception of the excessive accumulation of lipofuscin in the hepatocytes of these dogs, no test compound-related pathological changes in other tissues of the body were observed. Analysis of the urine revealed the presence of small amounts of N-oxidation products (1-nitrosonaphthalene plus N-hydroxy-1-naphthylamine). ranging from 2.85 to 125 μg, following a dose of 1-naphthylamine. The theoretical significance of these findings is discussed.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Oct 1 1980|
ASJC Scopus subject areas
- Cancer Research