Failure of nimodipine to prevent ischemic neuronal damage in rats

Suvimol Vibulsresth, W. Dalton Dietrich, Raul Busto, Myron D. Ginsberg

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The efficacy of nimodipine in preventing ischemic brain injury was tested in rats subjected to a 20-minute period of high-grade forebrain ischemia by 4-vessel occlusion. Three minutes after restoration of circulation to the brain, an intravenous bolus of 5 μg/kg nimodipine or an equivalent amount of vehicle or saline was given, followed by continuous intravenous infusion of the respective solution at 1 μg/kg/min for 2 hours. In a second series, a larger bolus (20 μg/kg of nimodipine) and longer infusion period (6 hours) were employed. Histopathology of the brain was evaluated blindly 72 hours later and graded on a conventional 3-point scale. There was no significant effect of treatment in either series. In the 6-hour series, the percent of cerebral hemispheres showing damage of Grades 2 or 3 in zone CA1 of the hippocampus and in the striatum, respectively, was 100 and 40% for the nimodipine-treated rats, 100 and 42% for rats receiving vehicle, and 75 and 25% for animals receiving saline. Thus, this study revealed no beneficial effect of nimodipine when given following a 20-minute period of severe forebrain ischemia.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalStroke
Volume18
Issue number1
DOIs
StatePublished - Jan 1 1987

Keywords

  • Four-vessel occlusion
  • Ischemic neuronal damage
  • Nimodipine
  • Rats

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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