Failure of nimodipine to prevent ischemic neuronal damage in rats

S. Vibulsresth, W. Dalton Dietrich, R. Busto, Myron Ginsberg

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The efficacy of nimodipine in preventing ischemic brain injury was tested in rats subjected to a 20-minute period of high-grade forebrain ischemia by 4-vessel occlusion. Three minutes after restoration of circulation to the brain, an intravenous bolus of 5 μg/kg nimodipine or an equivalent amount of vehicle or saline was given, followed by continuous intravenous infusion of the respective solution at 1 μg/kg/min for 2 hours. In a second series, a larger bolus (20 μg/kg of nimodipine) and longer infusion period (6 hours) were employed. Histopathology of the brain was evaluated blindly 72 hours later and graded on a conventional 3-point scale. There was no significant effect of treatment in either series. In the 6-hour series, the percent of cerebral hemispheres showing damage of Grades 2 or 3 in zone CA1 of the hippocampus and in the striatum, respectively, was 100 and 40% for the nimodipine-treated rats, 100 and 42% for rats receiving vehicle, and 75 and 25% for animals receiving saline. Thus, this study revealed no beneficial effect of nimodipine when given following a 20-minute period of severe forebrain ischemia.

Original languageEnglish
Pages (from-to)210-216
Number of pages7
JournalStroke
Volume18
Issue number1
StatePublished - Jan 1 1987

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Nimodipine
Prosencephalon
Ischemia
Brain
Cerebrum
Intravenous Infusions
Brain Injuries
Hippocampus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Failure of nimodipine to prevent ischemic neuronal damage in rats. / Vibulsresth, S.; Dalton Dietrich, W.; Busto, R.; Ginsberg, Myron.

In: Stroke, Vol. 18, No. 1, 01.01.1987, p. 210-216.

Research output: Contribution to journalArticle

Vibulsresth, S. ; Dalton Dietrich, W. ; Busto, R. ; Ginsberg, Myron. / Failure of nimodipine to prevent ischemic neuronal damage in rats. In: Stroke. 1987 ; Vol. 18, No. 1. pp. 210-216.
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