Failure of hypoxic pulmonary vasoconstriction in bronchial asthma

A. Wanner, M. A. Cohn, Horst J. Baier

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Hypoxia associated with antigen-induced bronchospasm in allergic dogs did not increase pulmonary vascular resistance in contrast to hypoxia produced by 10% oxygen breathing, hypoxia associated with antigen-induced bronchospasm was accompanied by an increase in pulmonary vascular resistance in animals pretreated with prostaglandin inhibitors, prostaglandin inhibitors produced an increase in pulmonary vascular resistance during antigen-induced bronchospasm by restoring a blunted hypoxic pulmonary vasoconstrictor response since this effect was not observed in animals in whom bronchospasm-associated hypoxia was prevented by 80% oxygen breathing, this unmasking effect of prostaglandin inhibitors on hypoxic pulmonary vasoconstriction required the presence of antigen-induced bronchospasm since it did not occur in animals in whom hypoxia was produced by 10% oxygen breathing without induced bronchospasm, and for comparable degrees of bronchospasm, the resulting arterial hypoxaemia was less severe in the animals pretreated with prostaglandins inhibitors. These results suggest that in acute experimental canine asthma, vasodilator prostaglandins blunt the hypoxic pulmonary vasoconstrictor response thereby further compromising gas exchange but preventing the development of pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)180-181
Number of pages2
JournalBulletin of the International Union against Tuberculosis
Issue number2
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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