Failure of fluosol to influence the incidence of cerebral infarction or mortality in gerbils subjected to temporary carotid occlusion

Sastry Kolluri, Roberto C. Heros, J. P. Vonsattel, E. Tessa Hedley-Whyte, Donald Miller, Nicholas T. Zervas

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Three hundred two gerbils were subjected to 2, 4, or 6 hours of temporary occlusion of the right common carotid artery. The animals were divided into four groups. The first two groups were given an infusion of Fluosol DA 20% (20 ml/kg) before arterial occlusion. One of these groups was kept in an environment of 100% oxygen during the time of occlusion and the other group was kept in room air. The two other groups of animals did not receive Fluosol. One of these groups was kept in 100% oxygen and the other group in room air during the time of arterial occlusion. The surviving animals were sacrificed 7 days later, and their brains were examined grossly and microscopically for evidence of cerebral infarction. There was a lesser incidence of early hemiparesis in the two groups treated with Fluosol, as well as in the untreated group that was kept in 100% oxygen. However, the incidence of infarction and the mortality were not significantly different in any of the groups.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalSurgical neurology
Volume25
Issue number6
DOIs
StatePublished - Jun 1986
Externally publishedYes

Keywords

  • Carotid occlusion
  • Cerebral infarction
  • Fluosol
  • Gerbils
  • Perfluorochemicals

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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