Failure of ascorbic acid to inhibit fanft induced bladder cancer

M. S. Soloway, S. M. Cohen, J. B. Dekernion, L. Persky

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21 Scopus citations

Abstract

L ascorbic acid has been shown to reduce the elevated level of urinary chemiluminescence found in patients with bladder cancer. Thus, it has been suggested that vitamin C might be efficacious in bladder tumor prophylaxis. However, there is no clinical evidence to support this thesis. The authors evaluated whether L ascorbic acid given concomitantly with the urinary carcinogen N [4 (5 nitro 2 furyl) 2 thiazolyl]formamide (FANFT) was capable of reducing the incidence of subsequent bladder tumors. No inhibitory effect was observed. Unless evidence is obtained demonstrating bladder tumor prevention by L ascorbic acid its routine administration to patients with bladder cancer is not indicated.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalJournal of Urology
Volume113
Issue number4
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Urology

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    Soloway, M. S., Cohen, S. M., Dekernion, J. B., & Persky, L. (1975). Failure of ascorbic acid to inhibit fanft induced bladder cancer. Journal of Urology, 113(4), 483-486. https://doi.org/10.1016/S0022-5347(17)59506-3