Failure of ascorbic acid to inhibit fanft induced bladder cancer

M. S. Soloway, S. M. Cohen, J. B. Dekernion, L. Persky

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

L ascorbic acid has been shown to reduce the elevated level of urinary chemiluminescence found in patients with bladder cancer. Thus, it has been suggested that vitamin C might be efficacious in bladder tumor prophylaxis. However, there is no clinical evidence to support this thesis. The authors evaluated whether L ascorbic acid given concomitantly with the urinary carcinogen N [4 (5 nitro 2 furyl) 2 thiazolyl]formamide (FANFT) was capable of reducing the incidence of subsequent bladder tumors. No inhibitory effect was observed. Unless evidence is obtained demonstrating bladder tumor prevention by L ascorbic acid its routine administration to patients with bladder cancer is not indicated.

Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalJournal of Urology
Volume113
Issue number4
StatePublished - Dec 1 1975
Externally publishedYes

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Urinary Bladder Neoplasms
Ascorbic Acid
FANFT
Luminescence
Carcinogens
Incidence

ASJC Scopus subject areas

  • Urology

Cite this

Soloway, M. S., Cohen, S. M., Dekernion, J. B., & Persky, L. (1975). Failure of ascorbic acid to inhibit fanft induced bladder cancer. Journal of Urology, 113(4), 483-486.

Failure of ascorbic acid to inhibit fanft induced bladder cancer. / Soloway, M. S.; Cohen, S. M.; Dekernion, J. B.; Persky, L.

In: Journal of Urology, Vol. 113, No. 4, 01.12.1975, p. 483-486.

Research output: Contribution to journalArticle

Soloway, MS, Cohen, SM, Dekernion, JB & Persky, L 1975, 'Failure of ascorbic acid to inhibit fanft induced bladder cancer', Journal of Urology, vol. 113, no. 4, pp. 483-486.
Soloway MS, Cohen SM, Dekernion JB, Persky L. Failure of ascorbic acid to inhibit fanft induced bladder cancer. Journal of Urology. 1975 Dec 1;113(4):483-486.
Soloway, M. S. ; Cohen, S. M. ; Dekernion, J. B. ; Persky, L. / Failure of ascorbic acid to inhibit fanft induced bladder cancer. In: Journal of Urology. 1975 ; Vol. 113, No. 4. pp. 483-486.
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