Factors influencing T-cell turnover in HIV-1-seropositive patients

Joseph M. McCune, Mary Beth Hanley, Denise Cesar, Robert Halvorsen, Rebecca Hoh, Diane Schmidt, Eric Wieder, Steven Decks, Scott Siler, Richard Neese, Marc Hellerstein

Research output: Contribution to journalArticle

186 Scopus citations

Abstract

HIV-1 disease is associated with pathological effects on T-cell production, destruction, and distribution. Using the deuterated (2H) glucose method for endogenous labeling, we have analyzed host factors that influence T-cell turnover in HIV-1-uninfected and -infected humans. In untreated HIV-1 disease, the average half life of circulating T cells was diminished without compensatory increases in cell production. Within 12 weeks of the initiation of highly active antiretroviral therapy (HAART), the absolute production rates of circulating T cells increased, and normal half-lives and production rates were restored by 12-36 months. Interpatient heterogeneity in the absolute degree of turnover correlated with the relative proportion of naive- and memory/effector-phenotype T cells in each of the CD4+ and CD8+ populations. The half-lives of naive-phenotype T cells ranged from 116-365 days (fractional replacement rates of 0.19-0.60% per day), whereas memory/effector-phenotype T cells persisted with half-lives from 22-79 days (fractional replacement rates of 0.87-3.14% per day). Naive-phenotype T cells were more abundant, and the half-life of total T cells was prolonged in individuals with abundant thymic tissue, as assessed by computed tomography. Such interpatient variation in T-cell kinetics may be reflective of differences in functional immune reconstitution after treatment for HIV-1 disease.

Original languageEnglish (US)
Pages (from-to)R1-R8
JournalJournal of Clinical Investigation
Volume105
Issue number5
DOIs
StatePublished - Mar 2000

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Factors influencing T-cell turnover in HIV-1-seropositive patients'. Together they form a unique fingerprint.

  • Cite this

    McCune, J. M., Hanley, M. B., Cesar, D., Halvorsen, R., Hoh, R., Schmidt, D., Wieder, E., Decks, S., Siler, S., Neese, R., & Hellerstein, M. (2000). Factors influencing T-cell turnover in HIV-1-seropositive patients. Journal of Clinical Investigation, 105(5), R1-R8. https://doi.org/10.1172/JCI8647