Factors controlling hair-cell regeneration/repair in the inner ear

Hinrich Staecker, Thomas R. Van De Water

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Damaged hair cells in the avian basilar papilla are replaced by regenerative proliferation of supporting cells and transdifferentiation of supporting cells into hair cells. In the mammalian vestibular system, transdifferentiation and, possibly, the repair of damaged hair cells appear to play significant roles. Several growth factors have been found to be associated with the regeneration/repair process: insulin, insulin-like growth factor 1 (IGF-1), and fibroblast growth factors are important for avian inner ear regeneration/repair, whereas epidermal growth factor, transforming growth factor α, insulin, IGF-1, and IGF-2 are important for regeneration/repair in the mammalian labyrinth. Increasing evidence suggests that regeneration/repair of mammalian auditory hair cells is possible during the early neonatal period and may exist to a very limited degree at later times.

Original languageEnglish (US)
Pages (from-to)480-487
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume8
Issue number4
DOIs
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Neuroscience(all)

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