Factors associated with severe intracranial hypertension in candidates for emergency liver transplantation

Santiago J. Muñoz, Michael J. Morirz, Rodney Bell, Bruce Northrup, Paul Martin, John Radomski

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Cerebral edema is the leading cause of death in patients with fulminant hepatic failure (FHF). Emergency OLT is often a life-saving therapy for FHF but severe cerebral edema is a contraindication to transplantation. We attempted to identify clinical and biochemical factors associated with the development of severe intracranial hypertension in FHF. Fever, psychomotor agitation, and arterial hypertension were more frequently observed preceding episodes of severe intracranial hypertension, and more than 50% of FHF patients with uncontrolled intracranial hypertension sustained severe brain injury in our series. These observations suggest that vigorous treatment of fever, arterial hypertension, and agitation are important aspects of the intensive care management of FHF patients to maintain their OLT candidacy.

Original languageEnglish (US)
Pages (from-to)1071-1074
Number of pages4
JournalTransplantation
Volume55
Issue number5
DOIs
StatePublished - May 1993
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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