Factors associated with functional recovery in bipolar disorder patients

Aliza P. Wingo, Ross J. Baldessarini, Paul E. Holtzheimer, Philip D. Harvey

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Objectives: Among bipolar disorder (BPD) patients, functional recovery, defined as regaining individual premorbid residential and vocational status, is far less common than symptomatic recovery. As several factors have tentatively been implicated in outcomes in BPD, we investigated predictors of functional recovery among BPD patients, including demographic, clinical, and neurocognitive factors. Methods: We assessed functional recovery status with standardized residential and occupational indices, assessed neurocognitive functioning with performance-based neuropsychological tests, and collected demographic and clinical information for 65 euthymic or residually depressed Structured Clinical Interview for DSM-IV-defined type I or II BPD patients. We examined predictors of functional recovery with multiple logistic regression modeling. Results: More education (p = 0.006), fewer years of illness (p = 0.037), and being married (p = 0.045) were associated independently with functional recovery, even after controlling for residual depressive symptoms, diagnostic type (I versus II), and psychiatric comorbidity. Functionally unrecovered BPD patients performed less well than recovered patients on verbal fluency (effect size = 0.54, p = 0.03), a measure of executive functioning, but this difference was not significant when adjusted for residual mood symptoms and education. Conclusions: Among euthymic or mildly depressed BPD patients, functional recovery was associated with more education, being married, and fewer years of illness.

Original languageEnglish (US)
Pages (from-to)319-326
Number of pages8
JournalBipolar Disorders
Issue number3
StatePublished - May 2010
Externally publishedYes


  • Bipolar disorder
  • Education
  • Functional recovery
  • Illness duration
  • Marital status
  • Neurocognition

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Factors associated with functional recovery in bipolar disorder patients'. Together they form a unique fingerprint.

Cite this