Factors associated with functional recovery in bipolar disorder patients

Aliza P. Wingo, Ross J. Baldessarini, Paul E. Holtzheimer, Philip D Harvey

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objectives: Among bipolar disorder (BPD) patients, functional recovery, defined as regaining individual premorbid residential and vocational status, is far less common than symptomatic recovery. As several factors have tentatively been implicated in outcomes in BPD, we investigated predictors of functional recovery among BPD patients, including demographic, clinical, and neurocognitive factors. Methods: We assessed functional recovery status with standardized residential and occupational indices, assessed neurocognitive functioning with performance-based neuropsychological tests, and collected demographic and clinical information for 65 euthymic or residually depressed Structured Clinical Interview for DSM-IV-defined type I or II BPD patients. We examined predictors of functional recovery with multiple logistic regression modeling. Results: More education (p = 0.006), fewer years of illness (p = 0.037), and being married (p = 0.045) were associated independently with functional recovery, even after controlling for residual depressive symptoms, diagnostic type (I versus II), and psychiatric comorbidity. Functionally unrecovered BPD patients performed less well than recovered patients on verbal fluency (effect size = 0.54, p = 0.03), a measure of executive functioning, but this difference was not significant when adjusted for residual mood symptoms and education. Conclusions: Among euthymic or mildly depressed BPD patients, functional recovery was associated with more education, being married, and fewer years of illness.

Original languageEnglish
Pages (from-to)319-326
Number of pages8
JournalBipolar Disorders
Volume12
Issue number3
DOIs
StatePublished - May 1 2010
Externally publishedYes

Fingerprint

Bipolar Disorder
Education
Demography
Neuropsychological Tests
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Comorbidity
Logistic Models
Interviews
Depression

Keywords

  • Bipolar disorder
  • Education
  • Functional recovery
  • Illness duration
  • Marital status
  • Neurocognition

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Factors associated with functional recovery in bipolar disorder patients. / Wingo, Aliza P.; Baldessarini, Ross J.; Holtzheimer, Paul E.; Harvey, Philip D.

In: Bipolar Disorders, Vol. 12, No. 3, 01.05.2010, p. 319-326.

Research output: Contribution to journalArticle

Wingo, Aliza P. ; Baldessarini, Ross J. ; Holtzheimer, Paul E. ; Harvey, Philip D. / Factors associated with functional recovery in bipolar disorder patients. In: Bipolar Disorders. 2010 ; Vol. 12, No. 3. pp. 319-326.
@article{2a359cf738f34939a05190f640f0a0bb,
title = "Factors associated with functional recovery in bipolar disorder patients",
abstract = "Objectives: Among bipolar disorder (BPD) patients, functional recovery, defined as regaining individual premorbid residential and vocational status, is far less common than symptomatic recovery. As several factors have tentatively been implicated in outcomes in BPD, we investigated predictors of functional recovery among BPD patients, including demographic, clinical, and neurocognitive factors. Methods: We assessed functional recovery status with standardized residential and occupational indices, assessed neurocognitive functioning with performance-based neuropsychological tests, and collected demographic and clinical information for 65 euthymic or residually depressed Structured Clinical Interview for DSM-IV-defined type I or II BPD patients. We examined predictors of functional recovery with multiple logistic regression modeling. Results: More education (p = 0.006), fewer years of illness (p = 0.037), and being married (p = 0.045) were associated independently with functional recovery, even after controlling for residual depressive symptoms, diagnostic type (I versus II), and psychiatric comorbidity. Functionally unrecovered BPD patients performed less well than recovered patients on verbal fluency (effect size = 0.54, p = 0.03), a measure of executive functioning, but this difference was not significant when adjusted for residual mood symptoms and education. Conclusions: Among euthymic or mildly depressed BPD patients, functional recovery was associated with more education, being married, and fewer years of illness.",
keywords = "Bipolar disorder, Education, Functional recovery, Illness duration, Marital status, Neurocognition",
author = "Wingo, {Aliza P.} and Baldessarini, {Ross J.} and Holtzheimer, {Paul E.} and Harvey, {Philip D}",
year = "2010",
month = "5",
day = "1",
doi = "10.1111/j.1399-5618.2010.00808.x",
language = "English",
volume = "12",
pages = "319--326",
journal = "Bipolar Disorders",
issn = "1398-5647",
publisher = "Blackwell Munksgaard",
number = "3",

}

TY - JOUR

T1 - Factors associated with functional recovery in bipolar disorder patients

AU - Wingo, Aliza P.

AU - Baldessarini, Ross J.

AU - Holtzheimer, Paul E.

AU - Harvey, Philip D

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Objectives: Among bipolar disorder (BPD) patients, functional recovery, defined as regaining individual premorbid residential and vocational status, is far less common than symptomatic recovery. As several factors have tentatively been implicated in outcomes in BPD, we investigated predictors of functional recovery among BPD patients, including demographic, clinical, and neurocognitive factors. Methods: We assessed functional recovery status with standardized residential and occupational indices, assessed neurocognitive functioning with performance-based neuropsychological tests, and collected demographic and clinical information for 65 euthymic or residually depressed Structured Clinical Interview for DSM-IV-defined type I or II BPD patients. We examined predictors of functional recovery with multiple logistic regression modeling. Results: More education (p = 0.006), fewer years of illness (p = 0.037), and being married (p = 0.045) were associated independently with functional recovery, even after controlling for residual depressive symptoms, diagnostic type (I versus II), and psychiatric comorbidity. Functionally unrecovered BPD patients performed less well than recovered patients on verbal fluency (effect size = 0.54, p = 0.03), a measure of executive functioning, but this difference was not significant when adjusted for residual mood symptoms and education. Conclusions: Among euthymic or mildly depressed BPD patients, functional recovery was associated with more education, being married, and fewer years of illness.

AB - Objectives: Among bipolar disorder (BPD) patients, functional recovery, defined as regaining individual premorbid residential and vocational status, is far less common than symptomatic recovery. As several factors have tentatively been implicated in outcomes in BPD, we investigated predictors of functional recovery among BPD patients, including demographic, clinical, and neurocognitive factors. Methods: We assessed functional recovery status with standardized residential and occupational indices, assessed neurocognitive functioning with performance-based neuropsychological tests, and collected demographic and clinical information for 65 euthymic or residually depressed Structured Clinical Interview for DSM-IV-defined type I or II BPD patients. We examined predictors of functional recovery with multiple logistic regression modeling. Results: More education (p = 0.006), fewer years of illness (p = 0.037), and being married (p = 0.045) were associated independently with functional recovery, even after controlling for residual depressive symptoms, diagnostic type (I versus II), and psychiatric comorbidity. Functionally unrecovered BPD patients performed less well than recovered patients on verbal fluency (effect size = 0.54, p = 0.03), a measure of executive functioning, but this difference was not significant when adjusted for residual mood symptoms and education. Conclusions: Among euthymic or mildly depressed BPD patients, functional recovery was associated with more education, being married, and fewer years of illness.

KW - Bipolar disorder

KW - Education

KW - Functional recovery

KW - Illness duration

KW - Marital status

KW - Neurocognition

UR - http://www.scopus.com/inward/record.url?scp=77953923761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953923761&partnerID=8YFLogxK

U2 - 10.1111/j.1399-5618.2010.00808.x

DO - 10.1111/j.1399-5618.2010.00808.x

M3 - Article

VL - 12

SP - 319

EP - 326

JO - Bipolar Disorders

JF - Bipolar Disorders

SN - 1398-5647

IS - 3

ER -