TY - JOUR
T1 - Factors affecting microvascular responses in the bulbar conjunctiva in habitual contact lens wearers
AU - Hu, Liang
AU - Shi, Ce
AU - Jiang, Hong
AU - Shi, Yingying
AU - Sethi, Zubin
AU - Wang, Jianhua
N1 - Funding Information:
Supported by National Institutes of Health Center Grant P30 EY014801, and a grant from Research to Prevent Blindness. Disclosure: L. Hu, None; C. Shi, None; H. Jiang, None; Y. Shi, None; Z. Sethi, None; J. Wang, None
Publisher Copyright:
© 2018 The Authors.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/8
Y1 - 2018/8
N2 - PURPOSE. To investigate the factors affecting microvascular responses in the bulbar conjunctiva of habitual contact lens (HCL) wearers. METHODS. A functional slit-lamp biomicroscope (FSLB) was used to image the temporal bulbar conjunctiva of habitual contact lens (HCL) wearers and non–contact lens (NCL) wearers. The vessel diameters and blood flow velocities (BFVs) were measured. Fractal analysis using Dbox as vessel density and D0 as vessel complexity were used to quantitatively analyze the microvascular network. One eye each of 91 NCL wearers and 75 HCL wearers was imaged. RESULTS. The BFV of NCL wearers was 0.50 ± 0.14 mm/s, which was negatively correlated with age (r = -0.22, P < 0.05). The BFV, vessel diameter, Dbox, and D0 of HCL wearers was significantly higher than NCL wearers (P < 0.05). In these HCL wearers, BFVs were positively correlated with contact lens (CL) hours of wear per day and CL days of wear per week. BFV, Dbox, and D0 were not related to CL years of wear, CL power, CL base curve, and CL diameter (P > 0.05). CONCLUSIONS. Vascular responses on the bulbar conjunctiva occurred in HCL wearers and appeared to be unrelated to sex or age, CL years of wear, and lens parameters, indicating that wearing a CL itself may be the predominant factor inducing these responses.
AB - PURPOSE. To investigate the factors affecting microvascular responses in the bulbar conjunctiva of habitual contact lens (HCL) wearers. METHODS. A functional slit-lamp biomicroscope (FSLB) was used to image the temporal bulbar conjunctiva of habitual contact lens (HCL) wearers and non–contact lens (NCL) wearers. The vessel diameters and blood flow velocities (BFVs) were measured. Fractal analysis using Dbox as vessel density and D0 as vessel complexity were used to quantitatively analyze the microvascular network. One eye each of 91 NCL wearers and 75 HCL wearers was imaged. RESULTS. The BFV of NCL wearers was 0.50 ± 0.14 mm/s, which was negatively correlated with age (r = -0.22, P < 0.05). The BFV, vessel diameter, Dbox, and D0 of HCL wearers was significantly higher than NCL wearers (P < 0.05). In these HCL wearers, BFVs were positively correlated with contact lens (CL) hours of wear per day and CL days of wear per week. BFV, Dbox, and D0 were not related to CL years of wear, CL power, CL base curve, and CL diameter (P > 0.05). CONCLUSIONS. Vascular responses on the bulbar conjunctiva occurred in HCL wearers and appeared to be unrelated to sex or age, CL years of wear, and lens parameters, indicating that wearing a CL itself may be the predominant factor inducing these responses.
KW - Blood flow velocity
KW - Bulbar conjunctiva
KW - Functional slit-lamp biomicroscopy (FSLB)
KW - Hemodynamics
KW - Microvascular network
UR - http://www.scopus.com/inward/record.url?scp=85051552605&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051552605&partnerID=8YFLogxK
U2 - 10.1167/iovs.18-24216
DO - 10.1167/iovs.18-24216
M3 - Article
C2 - 30098199
AN - SCOPUS:85051552605
VL - 59
SP - 4108
EP - 4114
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 10
ER -