Factors affecting microvascular responses in the bulbar conjunctiva in habitual contact lens wearers

Liang Hu, Ce Shi, Hong Jiang, Yingying Shi, Zubin Sethi, Jianhua Wang

Research output: Contribution to journalArticle

1 Scopus citations


PURPOSE. To investigate the factors affecting microvascular responses in the bulbar conjunctiva of habitual contact lens (HCL) wearers. METHODS. A functional slit-lamp biomicroscope (FSLB) was used to image the temporal bulbar conjunctiva of habitual contact lens (HCL) wearers and non–contact lens (NCL) wearers. The vessel diameters and blood flow velocities (BFVs) were measured. Fractal analysis using Dbox as vessel density and D0 as vessel complexity were used to quantitatively analyze the microvascular network. One eye each of 91 NCL wearers and 75 HCL wearers was imaged. RESULTS. The BFV of NCL wearers was 0.50 ± 0.14 mm/s, which was negatively correlated with age (r = -0.22, P < 0.05). The BFV, vessel diameter, Dbox, and D0 of HCL wearers was significantly higher than NCL wearers (P < 0.05). In these HCL wearers, BFVs were positively correlated with contact lens (CL) hours of wear per day and CL days of wear per week. BFV, Dbox, and D0 were not related to CL years of wear, CL power, CL base curve, and CL diameter (P > 0.05). CONCLUSIONS. Vascular responses on the bulbar conjunctiva occurred in HCL wearers and appeared to be unrelated to sex or age, CL years of wear, and lens parameters, indicating that wearing a CL itself may be the predominant factor inducing these responses.

Original languageEnglish (US)
Pages (from-to)4108-4114
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number10
StatePublished - Aug 1 2018



  • Blood flow velocity
  • Bulbar conjunctiva
  • Functional slit-lamp biomicroscopy (FSLB)
  • Hemodynamics
  • Microvascular network

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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