Factors affecting hemodynamic changes after reperfusion in liver transplantation

Kalliopi K. Tsinari, Evangelos P. Misiakos, Maria A. Chatzipetrou, Alexandre Bakonyi Neto, Juan Carlos Llanos, Katerina V. Lampadariou, Concha T. Lawand, Michael Safioleas, Antony R. Gyamfi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The aim of this retrospective study was to determine if the duration of cold and warm ischemia times is related to the extent of these disturbances and also to identify other factors related to recipient's condition which may affect the severity of post reperfusion syndrome. Patients and methods. The authors studied the factors affecting hemodynamic changes after reperfusion in sixty-one patients submitted to liver transplantation at the University of Miami (Jackson Memorial Hospital) during the investigation period (August 1998-January 1999). The hemodynamic parameters monitored were heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary arterial pressure (MPAP), venous oxygen saturation (SVO 2) and ASA status. All parameters were evaluated in three specific times: after skin incision (baseline, T 1), 10 min. before reperfusion (T 2), and 10 min. after reperfusion (T 3). The statistical analyses were t-test for independent samples and ANOVA test. Results: All parameters changed significantly (p < 0.0001) at T 1, T 2 and T 3. No correlation was found between cold and warm ischemia times and any of hemodynamic parameters in our study and no correlation was found between gender and those parameters. Age was significantly correlated with the MAP at T 2. MAP was decreased in older patients at T 2. HR, MAP, CVP, PAP and CVO 2 were significantly correlated with ASA classification (p < 0.000033). Conclusions: No significant effects of cold and warm ischemia times on the hemodynamic intraoperative condition of the OLT were found. Furthermore, patients with a high ASA status were shown to be at an increased risk of cardiovascular collapse after reperfusion.

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalGED - Gastrenterologia Endoscopia Digestiva
Volume23
Issue number5
StatePublished - Sep 1 2004
Externally publishedYes

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Liver Transplantation
Reperfusion
Arterial Pressure
Cold Ischemia
Warm Ischemia
Hemodynamics
Central Venous Pressure
Heart Rate
Analysis of Variance
Retrospective Studies
Oxygen
Lung
Skin

Keywords

  • Cardiovascular system effects
  • Cold ischemia time
  • Liver transplantation
  • Warm ischemia time

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Tsinari, K. K., Misiakos, E. P., Chatzipetrou, M. A., Neto, A. B., Llanos, J. C., Lampadariou, K. V., ... Gyamfi, A. R. (2004). Factors affecting hemodynamic changes after reperfusion in liver transplantation. GED - Gastrenterologia Endoscopia Digestiva, 23(5), 216-220.

Factors affecting hemodynamic changes after reperfusion in liver transplantation. / Tsinari, Kalliopi K.; Misiakos, Evangelos P.; Chatzipetrou, Maria A.; Neto, Alexandre Bakonyi; Llanos, Juan Carlos; Lampadariou, Katerina V.; Lawand, Concha T.; Safioleas, Michael; Gyamfi, Antony R.

In: GED - Gastrenterologia Endoscopia Digestiva, Vol. 23, No. 5, 01.09.2004, p. 216-220.

Research output: Contribution to journalArticle

Tsinari, KK, Misiakos, EP, Chatzipetrou, MA, Neto, AB, Llanos, JC, Lampadariou, KV, Lawand, CT, Safioleas, M & Gyamfi, AR 2004, 'Factors affecting hemodynamic changes after reperfusion in liver transplantation', GED - Gastrenterologia Endoscopia Digestiva, vol. 23, no. 5, pp. 216-220.
Tsinari KK, Misiakos EP, Chatzipetrou MA, Neto AB, Llanos JC, Lampadariou KV et al. Factors affecting hemodynamic changes after reperfusion in liver transplantation. GED - Gastrenterologia Endoscopia Digestiva. 2004 Sep 1;23(5):216-220.
Tsinari, Kalliopi K. ; Misiakos, Evangelos P. ; Chatzipetrou, Maria A. ; Neto, Alexandre Bakonyi ; Llanos, Juan Carlos ; Lampadariou, Katerina V. ; Lawand, Concha T. ; Safioleas, Michael ; Gyamfi, Antony R. / Factors affecting hemodynamic changes after reperfusion in liver transplantation. In: GED - Gastrenterologia Endoscopia Digestiva. 2004 ; Vol. 23, No. 5. pp. 216-220.
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AU - Misiakos, Evangelos P.

AU - Chatzipetrou, Maria A.

AU - Neto, Alexandre Bakonyi

AU - Llanos, Juan Carlos

AU - Lampadariou, Katerina V.

AU - Lawand, Concha T.

AU - Safioleas, Michael

AU - Gyamfi, Antony R.

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AB - Background: The aim of this retrospective study was to determine if the duration of cold and warm ischemia times is related to the extent of these disturbances and also to identify other factors related to recipient's condition which may affect the severity of post reperfusion syndrome. Patients and methods. The authors studied the factors affecting hemodynamic changes after reperfusion in sixty-one patients submitted to liver transplantation at the University of Miami (Jackson Memorial Hospital) during the investigation period (August 1998-January 1999). The hemodynamic parameters monitored were heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary arterial pressure (MPAP), venous oxygen saturation (SVO 2) and ASA status. All parameters were evaluated in three specific times: after skin incision (baseline, T 1), 10 min. before reperfusion (T 2), and 10 min. after reperfusion (T 3). The statistical analyses were t-test for independent samples and ANOVA test. Results: All parameters changed significantly (p < 0.0001) at T 1, T 2 and T 3. No correlation was found between cold and warm ischemia times and any of hemodynamic parameters in our study and no correlation was found between gender and those parameters. Age was significantly correlated with the MAP at T 2. MAP was decreased in older patients at T 2. HR, MAP, CVP, PAP and CVO 2 were significantly correlated with ASA classification (p < 0.000033). Conclusions: No significant effects of cold and warm ischemia times on the hemodynamic intraoperative condition of the OLT were found. Furthermore, patients with a high ASA status were shown to be at an increased risk of cardiovascular collapse after reperfusion.

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