Factor v leiden mutation is a risk factor for hepatic artery thrombosis in liver transplantation

Ji Fan, S. Nishida, G. Selvaggi, D. Levi, A. Tekin, D. Weppler, A. G. Tzakis

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Hepatic artery thrombosis (HAT) after orthotopic liver transplantation (OLT) is associated with significant morbidity and mortality. Factor V Leiden (FVL) mutation is the most common genetic defect that predisposes to thrombosis. The reconstruction of hepatic artery with arterial graft is a documented risk factor for HAT. However, the relationship among FVL mutation, arterial graft, and HAT remains to be determined. Methods: We randomly genotyped 485 patients who underwent OLT from April 2002 to January 2011 and studied the incidence of Hepatic artery thrombosis in the presence of FVL mutation. Results: Of 485 patients, 21 patients (4.3%) developed HAT (13 male, 8 female); 10 patients (4 male, 6 female) were heterozygous for the FVL mutation. The incidences of HAT in patients without versus with the FVL mutation were 3.8% and 30% (P =.007). Of patients with HAT, 8 hepatic arteries were reconstructed with infrarenal aortic conduits. All 3 patients (100%) with vs 5 (28%) without FVL who received arterial grafts developed HAT (P =.042). Conclusion: Our study suggested that the FVL mutation may be a risk factor for HAT in liver transplantation; the risk is augmented in the presence of an arterial graft.

Original languageEnglish (US)
Pages (from-to)1990-1993
Number of pages4
JournalTransplantation proceedings
Volume45
Issue number5
DOIs
StatePublished - Jun 1 2013

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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