Factor v leiden mutation is a risk factor for hepatic artery thrombosis in liver transplantation

J. Fan, Seigo Nishida, Gennaro Selvaggi, D. Levi, Akin Tekin, D. Weppler, A. G. Tzakis

Research output: Contribution to journalArticle

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Abstract

Background: Hepatic artery thrombosis (HAT) after orthotopic liver transplantation (OLT) is associated with significant morbidity and mortality. Factor V Leiden (FVL) mutation is the most common genetic defect that predisposes to thrombosis. The reconstruction of hepatic artery with arterial graft is a documented risk factor for HAT. However, the relationship among FVL mutation, arterial graft, and HAT remains to be determined. Methods: We randomly genotyped 485 patients who underwent OLT from April 2002 to January 2011 and studied the incidence of Hepatic artery thrombosis in the presence of FVL mutation. Results: Of 485 patients, 21 patients (4.3%) developed HAT (13 male, 8 female); 10 patients (4 male, 6 female) were heterozygous for the FVL mutation. The incidences of HAT in patients without versus with the FVL mutation were 3.8% and 30% (P =.007). Of patients with HAT, 8 hepatic arteries were reconstructed with infrarenal aortic conduits. All 3 patients (100%) with vs 5 (28%) without FVL who received arterial grafts developed HAT (P =.042). Conclusion: Our study suggested that the FVL mutation may be a risk factor for HAT in liver transplantation; the risk is augmented in the presence of an arterial graft.

Original languageEnglish
Pages (from-to)1990-1993
Number of pages4
JournalTransplantation Proceedings
Volume45
Issue number5
DOIs
StatePublished - Jun 1 2013

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Hepatic Artery
Liver Transplantation
Thrombosis
Mutation
Transplants
Incidence
factor V Leiden
Morbidity

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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Factor v leiden mutation is a risk factor for hepatic artery thrombosis in liver transplantation. / Fan, J.; Nishida, Seigo; Selvaggi, Gennaro; Levi, D.; Tekin, Akin; Weppler, D.; Tzakis, A. G.

In: Transplantation Proceedings, Vol. 45, No. 5, 01.06.2013, p. 1990-1993.

Research output: Contribution to journalArticle

Fan, J. ; Nishida, Seigo ; Selvaggi, Gennaro ; Levi, D. ; Tekin, Akin ; Weppler, D. ; Tzakis, A. G. / Factor v leiden mutation is a risk factor for hepatic artery thrombosis in liver transplantation. In: Transplantation Proceedings. 2013 ; Vol. 45, No. 5. pp. 1990-1993.
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AU - Weppler, D.

AU - Tzakis, A. G.

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