Factor v leiden mutation in reocclusion after intra-arterial thrombolysis

Abraham Kuruvilla, Gregory M. Norris, Sunil Manjila, Andrew R. Xavier, Seemant Chaturvedi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background and Purpose-Reocclusion of intracranial arteries after successful recanalization is associated with poor clinical outcome. The role of Factor V Leiden mutation in intracranial arterial thrombosis/rethrombosis is unclear. Summary of Report-We report the case of a patient who developed recurrent reocclusions of the middle cerebral artery after intra-arterial thrombolysis for acute ischemic stroke. The patient subsequently underwent transcatheter clot retrieval followed by successful stent-supported angioplasty of the occluded segment. He underwent a detailed workup for thrombophilia. The patient was detected to be heterozygous for Factor V Leiden mutation without any other cause for thrombophilia. Conclusions-Factor V Leiden mutation could be a contributing etiology for reocclusion after endovascular interventions in stroke. Systematic studies looking for thrombophilic mutations in patients with arterial reocclusion might be warranted.

Original languageEnglish (US)
Pages (from-to)660-662
Number of pages3
Issue number2
StatePublished - Feb 2009
Externally publishedYes


  • Acute stroke
  • Factor v leiden
  • Reocclusions
  • RtPA
  • Thrombolysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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