Factor structure of cognition and functional capacity in two studies of schizophrenia and bipolar disorder: Implications for genomic studies

Philip D Harvey, Mihaela Aslan, Mengtian Du, Hongyu Zhao, Larry J. Siever, Ann Pulver, J. Michael Gaziano, John Concato

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Impairments in cognition and everyday functioning are common in schizophrenia and bipolar disorder (BPD). In this article, we present factor analyses of cognitive and functional capacity (FC) measures based on 2 studies of schizophrenia (SCZ) and bipolar I disorder (BPI) using similar methods. The overall goal of these analyses was to determine whether performance-based assessments should be examined individually, or aggregated on the basis of the correlational structure of the tests, as well as to evaluate the similarity of factor structures of SCZ and BPI. Method: Veterans Affairs Cooperative Studies Program Study #572 (Harvey et al., 2014) evaluated cognitive and FC measures among 5,414 BPI and 3,942 SCZ patients. A 2nd study evaluated similar neuropsychological (NP) and FC measures among 368 BPI and 436 SCZ patients. Principal components analysis, as well as exploratory and CFAs, were used to examine the data. Results: Analyses in both datasets suggested that NP and FC measures were explained by a single underlying factor in BPI and SCZ patients, both when analyzed separately or as in a combined sample. The factor structure in both studies was similar, with or without inclusion of FC measures; homogeneous loadings were observed for that single factor across cognitive and FC domains across the samples. Conclusion: The empirically derived factor model suggests that NP performance and FC are best explained as a single latent trait applicable to people with SCZ and BPD. This single measure may enhance the robustness of the analyses relating genomic data to performance-based phenotypes.

Original languageEnglish (US)
Pages (from-to)28-39
Number of pages12
JournalNeuropsychology
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2016

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Bipolar Disorder
Cognition
Schizophrenia
Veterans
Principal Component Analysis
Statistical Factor Analysis
Phenotype

Keywords

  • Bipolar disorder
  • Cognition
  • Factor analysis
  • Functional capacity
  • Schizophrenia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Factor structure of cognition and functional capacity in two studies of schizophrenia and bipolar disorder : Implications for genomic studies. / Harvey, Philip D; Aslan, Mihaela; Du, Mengtian; Zhao, Hongyu; Siever, Larry J.; Pulver, Ann; Michael Gaziano, J.; Concato, John.

In: Neuropsychology, Vol. 30, No. 1, 01.01.2016, p. 28-39.

Research output: Contribution to journalArticle

Harvey, Philip D ; Aslan, Mihaela ; Du, Mengtian ; Zhao, Hongyu ; Siever, Larry J. ; Pulver, Ann ; Michael Gaziano, J. ; Concato, John. / Factor structure of cognition and functional capacity in two studies of schizophrenia and bipolar disorder : Implications for genomic studies. In: Neuropsychology. 2016 ; Vol. 30, No. 1. pp. 28-39.
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