Factor analysis of restricted and repetitive behaviors in autism using the autism diagnostic interview-R

Michael Cuccaro, Yujan Shao, Janet Grubber, Michael Slifer, Chantelle M. Wolpert, Shannon L. Donnelly, Ruth K. Abramson, Sarah A. Ravan, Harry H. Wright, G. Robert DeLong, Margaret A Pericak-Vance

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

The current study examined the factor structure of restricted and repetitive behaviors (RRB) in children with autism. Factor extraction procedures of 12 items from the Autism Diagnostic Interview-Revised (ADI-R) were applied in N = 207 individuals with autism. Two interpretable factors were identified: Factor 1-repetitive sensory motor actions and Factor 2-resistance to change. There was a significant negative correlation between an index of level of adaptive functioning and Factor 1. Intraclass correlations were not significant for either factor in a subset of families with two or more siblings with autism (multiplex). No differences in scores were apparent for either factor when multiplex families and families containing only one affected individual with autism (singleton) were compared. RRB in autism are represented by two distinct factors which may reflect two separate groups within autism. Defining subgroups within autism will allow for reduction of clinical heterogeneity and enhance our ability to dissect the genetic etiology of this complex disorder.

Original languageEnglish
Pages (from-to)3-17
Number of pages15
JournalChild Psychiatry and Human Development
Volume34
Issue number1
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Fingerprint

Autistic Disorder
Statistical Factor Analysis
Interviews
Aptitude
R Factors
Child Behavior

Keywords

  • Autism
  • Factor analysis
  • Repetitive behaviors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Factor analysis of restricted and repetitive behaviors in autism using the autism diagnostic interview-R. / Cuccaro, Michael; Shao, Yujan; Grubber, Janet; Slifer, Michael; Wolpert, Chantelle M.; Donnelly, Shannon L.; Abramson, Ruth K.; Ravan, Sarah A.; Wright, Harry H.; DeLong, G. Robert; Pericak-Vance, Margaret A.

In: Child Psychiatry and Human Development, Vol. 34, No. 1, 01.09.2003, p. 3-17.

Research output: Contribution to journalArticle

Cuccaro, M, Shao, Y, Grubber, J, Slifer, M, Wolpert, CM, Donnelly, SL, Abramson, RK, Ravan, SA, Wright, HH, DeLong, GR & Pericak-Vance, MA 2003, 'Factor analysis of restricted and repetitive behaviors in autism using the autism diagnostic interview-R', Child Psychiatry and Human Development, vol. 34, no. 1, pp. 3-17. https://doi.org/10.1023/A:1025321707947
Cuccaro, Michael ; Shao, Yujan ; Grubber, Janet ; Slifer, Michael ; Wolpert, Chantelle M. ; Donnelly, Shannon L. ; Abramson, Ruth K. ; Ravan, Sarah A. ; Wright, Harry H. ; DeLong, G. Robert ; Pericak-Vance, Margaret A. / Factor analysis of restricted and repetitive behaviors in autism using the autism diagnostic interview-R. In: Child Psychiatry and Human Development. 2003 ; Vol. 34, No. 1. pp. 3-17.
@article{10f0fe69df1c45068bc112cfdcbc49cb,
title = "Factor analysis of restricted and repetitive behaviors in autism using the autism diagnostic interview-R",
abstract = "The current study examined the factor structure of restricted and repetitive behaviors (RRB) in children with autism. Factor extraction procedures of 12 items from the Autism Diagnostic Interview-Revised (ADI-R) were applied in N = 207 individuals with autism. Two interpretable factors were identified: Factor 1-repetitive sensory motor actions and Factor 2-resistance to change. There was a significant negative correlation between an index of level of adaptive functioning and Factor 1. Intraclass correlations were not significant for either factor in a subset of families with two or more siblings with autism (multiplex). No differences in scores were apparent for either factor when multiplex families and families containing only one affected individual with autism (singleton) were compared. RRB in autism are represented by two distinct factors which may reflect two separate groups within autism. Defining subgroups within autism will allow for reduction of clinical heterogeneity and enhance our ability to dissect the genetic etiology of this complex disorder.",
keywords = "Autism, Factor analysis, Repetitive behaviors",
author = "Michael Cuccaro and Yujan Shao and Janet Grubber and Michael Slifer and Wolpert, {Chantelle M.} and Donnelly, {Shannon L.} and Abramson, {Ruth K.} and Ravan, {Sarah A.} and Wright, {Harry H.} and DeLong, {G. Robert} and Pericak-Vance, {Margaret A}",
year = "2003",
month = "9",
day = "1",
doi = "10.1023/A:1025321707947",
language = "English",
volume = "34",
pages = "3--17",
journal = "Child Psychiatry and Human Development",
issn = "0009-398X",
publisher = "Kluwer Academic/Human Sciences Press Inc.",
number = "1",

}

TY - JOUR

T1 - Factor analysis of restricted and repetitive behaviors in autism using the autism diagnostic interview-R

AU - Cuccaro, Michael

AU - Shao, Yujan

AU - Grubber, Janet

AU - Slifer, Michael

AU - Wolpert, Chantelle M.

AU - Donnelly, Shannon L.

AU - Abramson, Ruth K.

AU - Ravan, Sarah A.

AU - Wright, Harry H.

AU - DeLong, G. Robert

AU - Pericak-Vance, Margaret A

PY - 2003/9/1

Y1 - 2003/9/1

N2 - The current study examined the factor structure of restricted and repetitive behaviors (RRB) in children with autism. Factor extraction procedures of 12 items from the Autism Diagnostic Interview-Revised (ADI-R) were applied in N = 207 individuals with autism. Two interpretable factors were identified: Factor 1-repetitive sensory motor actions and Factor 2-resistance to change. There was a significant negative correlation between an index of level of adaptive functioning and Factor 1. Intraclass correlations were not significant for either factor in a subset of families with two or more siblings with autism (multiplex). No differences in scores were apparent for either factor when multiplex families and families containing only one affected individual with autism (singleton) were compared. RRB in autism are represented by two distinct factors which may reflect two separate groups within autism. Defining subgroups within autism will allow for reduction of clinical heterogeneity and enhance our ability to dissect the genetic etiology of this complex disorder.

AB - The current study examined the factor structure of restricted and repetitive behaviors (RRB) in children with autism. Factor extraction procedures of 12 items from the Autism Diagnostic Interview-Revised (ADI-R) were applied in N = 207 individuals with autism. Two interpretable factors were identified: Factor 1-repetitive sensory motor actions and Factor 2-resistance to change. There was a significant negative correlation between an index of level of adaptive functioning and Factor 1. Intraclass correlations were not significant for either factor in a subset of families with two or more siblings with autism (multiplex). No differences in scores were apparent for either factor when multiplex families and families containing only one affected individual with autism (singleton) were compared. RRB in autism are represented by two distinct factors which may reflect two separate groups within autism. Defining subgroups within autism will allow for reduction of clinical heterogeneity and enhance our ability to dissect the genetic etiology of this complex disorder.

KW - Autism

KW - Factor analysis

KW - Repetitive behaviors

UR - http://www.scopus.com/inward/record.url?scp=0043193924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0043193924&partnerID=8YFLogxK

U2 - 10.1023/A:1025321707947

DO - 10.1023/A:1025321707947

M3 - Article

C2 - 14518620

AN - SCOPUS:0043193924

VL - 34

SP - 3

EP - 17

JO - Child Psychiatry and Human Development

JF - Child Psychiatry and Human Development

SN - 0009-398X

IS - 1

ER -