Facilitating alzheimer disease research recruitment

Joshua D. Grill, James E. Galvin

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

Alzheimer disease (AD) research faces challenges to successful enrollment, especially to clinical trials and biomarker studies. Failure to recruit the planned number of participants in a timely manner threatens the internal validity and success of clinical research, raising concerns about external validity and generalizability of results, and possibly leading to disparities in disease treatment. Methods to improve recruitment exist, but require varying levels of staff effort and financial resources, and evidence of effectiveness is often lacking or inconsistent. In this review, we summarize some of the available methods to improve AD research recruitment, the available literature to support or refute these strategies, and some of the experiences at the authors' AD Research Centers. We discuss the use of community-based participatory research principles and participant registries as a means to enhance research enrollment and increase diversity of research samples.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAlzheimer disease and associated disorders
Volume28
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • Alzheimer disease
  • clinical trials
  • community-based participatory research
  • recruitment
  • registries
  • research participation

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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