Fabrication and characterization of a surface-acoustic-wave biosensor in cmos technology for cancer biomarker detection

Onur Tigli, Louis Bivona, Patricia Berg, Mona E. Zaghloul

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Design, fabrication, and characterization of a novel surface acoustic wave (SAW) biosensor in complementary metaloxide semiconductor (CMOS) technology are introduced. The biosensor employs a streptavidin/biotin-based five-layer immunoassay for detecting a prominent breast cancer biomarker, mammoglobin (hMAM). There is a growing demand to develop a sensitive and specific assay to detect biomarkers in serum that could be used in the early detection of breast cancer, determining prognosis and monitoring therapy. CMOS-SAW devices present a viable alternative to the existing biosensor technologies by providing higher sensitivity levels and better performance at low costs. Two architectures (circular and rectangular) were developed and respective tests were presented for performance comparison. The sensitivities of the devices were analyzed primarily based on center frequency shifts. A frequency sensitivity of 8.704 pg/Hz and a mass sensitivity of 2810.25 m$^{2} /$kg were obtained. Selectivity tests were carried out against bovine serum albumin. Experimental results indicate that it is possible to attach cancer biomarkers to functionalized CMOS-SAW sensor surfaces and selectively detect hMAM antigens with improved sensitivities, lowered costs, and increased repeatability of fabrication.

Original languageEnglish (US)
Article number5345716
Pages (from-to)62-73
Number of pages12
JournalIEEE Transactions on Biomedical Circuits and Systems
Volume4
Issue number1
DOIs
StatePublished - Feb 1 2010

Keywords

  • Biosensor
  • Cancer
  • Complementary metal–oxide semiconductor (CMOS)
  • Microelectromechanical systems (MEMS)
  • Surface acoustic wave (SAW)

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Biomedical Engineering

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