Eye-sparing treatment of localized orbital medulloepithelioma with neoadjuvant chemoradiation

Ryan A. Gallo, Jamie Shoag, Thomas E. Johnson, David A. Solomon, Arie Perry, Antonello Podda, John Y. Lee, Andrew J. Rong

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A 9-year-old girl presented with a 3-day history of progressive proptosis accompanied by transient discomfort and blurry vision in the OD. MRI revealed a heterogeneously enhancing intraconal lesion that partially encased and displaced the optic nerve. There was no intraocular or intracranial involvement, nor were there signs of distant metastasis. Histopathologic evaluation and immunohistochemistry were consistent with orbital medulloepithelioma. The patient received 4 cycles of chemoradiation per a retinoblastoma protocol. Repeat MRI scans showed significant tumor regression, and further surgical debulking was performed. There has been no evidence of recurrence for over 14 months. Herein, the authors describe an eye-sparing, multimodal treatment of a rare case of localized orbital medulloepithelioma.

Original languageEnglish (US)
Pages (from-to)E13-E16
JournalOphthalmic plastic and reconstructive surgery
StatePublished - Jan 1 2021

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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