Extraperitoneal pediatric kidney transplantation of adult renal allograft using an en-bloc native liver and kidney mobilization technique

Mahmoud Alameddine, Joshua S. Jue, Mahmoud Morsi, Javier Gonzalez, Marissa Defreitas, Jayanthi J. Chandar, Jeffrey J. Gaynor, Gaetano Ciancio

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We describe the safety and efficacy of performing pediatric kidney transplantation with a modified extraperitoneal approach that includes mobilization of the native liver and kidney. Methods: We retrospectively identified pediatric renal transplants performed using this technique between 2015 and 2019. Data on patient demographics, surgical technique, and intraoperative details were collected. Outcomes were measured by morbidity and re-operation at 90 days, as well as serum creatinine, allograft survival, and overall survival at 1 year. Results: Twenty-one patients with a median age of 5 (IQR 3–9) years, weighing 17.5 (IQR 14.5–24) kg were included. Median donor age was 24 (IQR 19–31) years. No intraoperative complications occurred. One child required a right native nephrectomy to allow sufficient space. Postoperatively, all patients had immediate graft function without urine leak or allograft thrombosis. 90-day morbidity and re-operation rates were zero. Both 1-year allograft and overall survival were 100% (on follow-up of all 21 patients through 1 year post-transplant), with a median serum creatinine of 0.58 (IQR 0.47–0.70) mg/dl at 1 year post-transplant. Conclusions: Pediatric kidney transplantation of adult renal allografts using an extraperitoneal approach with native liver and kidney mobilization has promising allograft and patient survival outcomes that eliminates peritoneal violation and may diminish the need for native nephrectomy.

Original languageEnglish (US)
Article number526
JournalBMC Pediatrics
Volume20
Issue number1
DOIs
StatePublished - Dec 2020

Keywords

  • Pediatric kidney transplantation
  • extraperitoneal approach
  • surgical technique

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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