Extracranial-intracranial bypass for stroke - Is this the end of the line or a bump in the road?

Sepideh Amin-Hanjani, Fred G. Barker, Fady T. Charbel, E. Sander Connolly, Jacques Morcos, B. Gregory Thompson

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The results of the recently published Carotid Occlusion Surgery Study, which failed to show a benefit of extracranial-intracranial (EC-IC) bypass over medical therapy in patients with symptomatic hemodynamically significant carotid occlusion, have been interpreted by some as the end of the line for EC-IC bypass in the management of stroke. Despite being carefully conceived and executed, several aspects of the trial design, study population, and underlying assumptions deserve further examination to determine how best to translate these results into clinical practice. Although a general expansion of EC-IC bypass use in this population would not be supported by the trial results, a select subset of patients with medically refractory hemodynamic symptoms may well benefit from surgery performed with sufficiently low perioperative morbidity. The potential for beneficial functional or cognitive impact of revascularization also remains under investigation. Limited application and further study with an eye to future developments, rather than complete abandonment, is warranted.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalNeurosurgery
Volume71
Issue number3
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

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Stroke
Population
Hemodynamics
Morbidity
Therapeutics

Keywords

  • Carotid occlusion
  • Extracranial-intracranial bypass
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Amin-Hanjani, S., Barker, F. G., Charbel, F. T., Connolly, E. S., Morcos, J., & Thompson, B. G. (2012). Extracranial-intracranial bypass for stroke - Is this the end of the line or a bump in the road? Neurosurgery, 71(3), 557-561. https://doi.org/10.1227/NEU.0b013e3182621488

Extracranial-intracranial bypass for stroke - Is this the end of the line or a bump in the road? / Amin-Hanjani, Sepideh; Barker, Fred G.; Charbel, Fady T.; Connolly, E. Sander; Morcos, Jacques; Thompson, B. Gregory.

In: Neurosurgery, Vol. 71, No. 3, 01.09.2012, p. 557-561.

Research output: Contribution to journalArticle

Amin-Hanjani, S, Barker, FG, Charbel, FT, Connolly, ES, Morcos, J & Thompson, BG 2012, 'Extracranial-intracranial bypass for stroke - Is this the end of the line or a bump in the road?', Neurosurgery, vol. 71, no. 3, pp. 557-561. https://doi.org/10.1227/NEU.0b013e3182621488
Amin-Hanjani, Sepideh ; Barker, Fred G. ; Charbel, Fady T. ; Connolly, E. Sander ; Morcos, Jacques ; Thompson, B. Gregory. / Extracranial-intracranial bypass for stroke - Is this the end of the line or a bump in the road?. In: Neurosurgery. 2012 ; Vol. 71, No. 3. pp. 557-561.
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