Extracranial glioblastoma in transplant recipients

Sopiko Jimsheleishvili, Ahmad T. Alshareef, Kyriakos Papadimitriou, Amade Bregy, Ashish H. Shah, Regina M Graham, Nicholas Ferraro, Ricardo J Komotar

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: Traditionally, gliomas are considered to be confined to the central nervous system. The shortage of solid donor organs resulted in consideration of organs from patients with primary malignancy such as glioblastoma multiforme (GBM) for transplantation into patients suffering from end-stage organ disease. Methods: We performed a PubMed search including all studies that documented patient demographics, pre- and post-transplantation conditions as well as time to metastasis and overall survival in recipients of organ transplants from donors suffering from GBM. Results: A total of 11 studies with 11 patients were included in this review. Three patients had liver, three had kidney, and five had lung transplantation. For kidney transplants, average time to metastasis was 17.3 months post-surgery. The average follow-up time was 32.3 months, and all patients were doing well. All liver transplant recipients succumbed due to GBM metastasis. The average survival was 7 months for all three patients. For lung-receiving patients, two patients died at an average of 9.5 months post-transplantation, with a mean time to metastasis of 9 months. Two patients were doing well at 17- and 20-month follow-up. One patient was diagnosed with metastasis 12 months after transplantation, but no follow-up data were provided. Conclusions: These studies emphasize the disadvantage of transplanting an organ of an individual with GBM. However, it should be noted that these cases do not make up a large percentage of overall transplantations, and donors with primary central nervous system malignancies also do not represent the whole pool of organs available.

Original languageEnglish
Pages (from-to)801-807
Number of pages7
JournalJournal of Cancer Research and Clinical Oncology
Volume140
Issue number5
DOIs
StatePublished - Jan 1 2014

Fingerprint

Glioblastoma
Transplantation
Neoplasm Metastasis
Tissue Donors
Transplant Recipients
Central Nervous System
Transplants
Kidney
Survival
Lung Transplantation
Liver
PubMed
Glioma
Neoplasms
Demography
Lung

Keywords

  • Brain neoplasm
  • Glioblastoma multiforme
  • Organ transplantation
  • Systematic analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Extracranial glioblastoma in transplant recipients. / Jimsheleishvili, Sopiko; Alshareef, Ahmad T.; Papadimitriou, Kyriakos; Bregy, Amade; Shah, Ashish H.; Graham, Regina M; Ferraro, Nicholas; Komotar, Ricardo J.

In: Journal of Cancer Research and Clinical Oncology, Vol. 140, No. 5, 01.01.2014, p. 801-807.

Research output: Contribution to journalArticle

Jimsheleishvili, S, Alshareef, AT, Papadimitriou, K, Bregy, A, Shah, AH, Graham, RM, Ferraro, N & Komotar, RJ 2014, 'Extracranial glioblastoma in transplant recipients', Journal of Cancer Research and Clinical Oncology, vol. 140, no. 5, pp. 801-807. https://doi.org/10.1007/s00432-014-1625-3
Jimsheleishvili S, Alshareef AT, Papadimitriou K, Bregy A, Shah AH, Graham RM et al. Extracranial glioblastoma in transplant recipients. Journal of Cancer Research and Clinical Oncology. 2014 Jan 1;140(5):801-807. https://doi.org/10.1007/s00432-014-1625-3
Jimsheleishvili, Sopiko ; Alshareef, Ahmad T. ; Papadimitriou, Kyriakos ; Bregy, Amade ; Shah, Ashish H. ; Graham, Regina M ; Ferraro, Nicholas ; Komotar, Ricardo J. / Extracranial glioblastoma in transplant recipients. In: Journal of Cancer Research and Clinical Oncology. 2014 ; Vol. 140, No. 5. pp. 801-807.
@article{0a0a5cce77f440b0a6d922a86f39d4b2,
title = "Extracranial glioblastoma in transplant recipients",
abstract = "Purpose: Traditionally, gliomas are considered to be confined to the central nervous system. The shortage of solid donor organs resulted in consideration of organs from patients with primary malignancy such as glioblastoma multiforme (GBM) for transplantation into patients suffering from end-stage organ disease. Methods: We performed a PubMed search including all studies that documented patient demographics, pre- and post-transplantation conditions as well as time to metastasis and overall survival in recipients of organ transplants from donors suffering from GBM. Results: A total of 11 studies with 11 patients were included in this review. Three patients had liver, three had kidney, and five had lung transplantation. For kidney transplants, average time to metastasis was 17.3 months post-surgery. The average follow-up time was 32.3 months, and all patients were doing well. All liver transplant recipients succumbed due to GBM metastasis. The average survival was 7 months for all three patients. For lung-receiving patients, two patients died at an average of 9.5 months post-transplantation, with a mean time to metastasis of 9 months. Two patients were doing well at 17- and 20-month follow-up. One patient was diagnosed with metastasis 12 months after transplantation, but no follow-up data were provided. Conclusions: These studies emphasize the disadvantage of transplanting an organ of an individual with GBM. However, it should be noted that these cases do not make up a large percentage of overall transplantations, and donors with primary central nervous system malignancies also do not represent the whole pool of organs available.",
keywords = "Brain neoplasm, Glioblastoma multiforme, Organ transplantation, Systematic analysis",
author = "Sopiko Jimsheleishvili and Alshareef, {Ahmad T.} and Kyriakos Papadimitriou and Amade Bregy and Shah, {Ashish H.} and Graham, {Regina M} and Nicholas Ferraro and Komotar, {Ricardo J}",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s00432-014-1625-3",
language = "English",
volume = "140",
pages = "801--807",
journal = "Journal of Cancer Research and Clinical Oncology",
issn = "0171-5216",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Extracranial glioblastoma in transplant recipients

AU - Jimsheleishvili, Sopiko

AU - Alshareef, Ahmad T.

AU - Papadimitriou, Kyriakos

AU - Bregy, Amade

AU - Shah, Ashish H.

AU - Graham, Regina M

AU - Ferraro, Nicholas

AU - Komotar, Ricardo J

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: Traditionally, gliomas are considered to be confined to the central nervous system. The shortage of solid donor organs resulted in consideration of organs from patients with primary malignancy such as glioblastoma multiforme (GBM) for transplantation into patients suffering from end-stage organ disease. Methods: We performed a PubMed search including all studies that documented patient demographics, pre- and post-transplantation conditions as well as time to metastasis and overall survival in recipients of organ transplants from donors suffering from GBM. Results: A total of 11 studies with 11 patients were included in this review. Three patients had liver, three had kidney, and five had lung transplantation. For kidney transplants, average time to metastasis was 17.3 months post-surgery. The average follow-up time was 32.3 months, and all patients were doing well. All liver transplant recipients succumbed due to GBM metastasis. The average survival was 7 months for all three patients. For lung-receiving patients, two patients died at an average of 9.5 months post-transplantation, with a mean time to metastasis of 9 months. Two patients were doing well at 17- and 20-month follow-up. One patient was diagnosed with metastasis 12 months after transplantation, but no follow-up data were provided. Conclusions: These studies emphasize the disadvantage of transplanting an organ of an individual with GBM. However, it should be noted that these cases do not make up a large percentage of overall transplantations, and donors with primary central nervous system malignancies also do not represent the whole pool of organs available.

AB - Purpose: Traditionally, gliomas are considered to be confined to the central nervous system. The shortage of solid donor organs resulted in consideration of organs from patients with primary malignancy such as glioblastoma multiforme (GBM) for transplantation into patients suffering from end-stage organ disease. Methods: We performed a PubMed search including all studies that documented patient demographics, pre- and post-transplantation conditions as well as time to metastasis and overall survival in recipients of organ transplants from donors suffering from GBM. Results: A total of 11 studies with 11 patients were included in this review. Three patients had liver, three had kidney, and five had lung transplantation. For kidney transplants, average time to metastasis was 17.3 months post-surgery. The average follow-up time was 32.3 months, and all patients were doing well. All liver transplant recipients succumbed due to GBM metastasis. The average survival was 7 months for all three patients. For lung-receiving patients, two patients died at an average of 9.5 months post-transplantation, with a mean time to metastasis of 9 months. Two patients were doing well at 17- and 20-month follow-up. One patient was diagnosed with metastasis 12 months after transplantation, but no follow-up data were provided. Conclusions: These studies emphasize the disadvantage of transplanting an organ of an individual with GBM. However, it should be noted that these cases do not make up a large percentage of overall transplantations, and donors with primary central nervous system malignancies also do not represent the whole pool of organs available.

KW - Brain neoplasm

KW - Glioblastoma multiforme

KW - Organ transplantation

KW - Systematic analysis

UR - http://www.scopus.com/inward/record.url?scp=84901595541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901595541&partnerID=8YFLogxK

U2 - 10.1007/s00432-014-1625-3

DO - 10.1007/s00432-014-1625-3

M3 - Article

C2 - 24595597

AN - SCOPUS:84901595541

VL - 140

SP - 801

EP - 807

JO - Journal of Cancer Research and Clinical Oncology

JF - Journal of Cancer Research and Clinical Oncology

SN - 0171-5216

IS - 5

ER -