Extracellular vesicles as therapeutic tools for the treatment of chronic wounds

Eric R. Bray, Alisha R. Oropallo, Daniel A. Grande, Robert S. Kirsner, Evangelos V Badiavas

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic wounds develop when the orderly process of cutaneous wound healing is delayed or disrupted. Development of a chronic wound is associated with significant morbidity and financial burden to the individual and health-care system. Therefore, new therapeutic modalities are needed to address this serious condition. Mesenchymal stem cells (MSCs) promote skin repair, but their clinical use has been limited due to technical challenges. Extracellular vesicles (EVs) are particles released by cells that carry bioactive molecules (lipids, proteins, and nucleic acids) and regulate intercellular communication. EVs (exosomes, microvesicles, and apoptotic bodies) mediate key therapeutic effects of MSCs. In this review we examine the experimental data establishing a role for EVs in wound healing. Then, we explore techniques for designing EVs to function as a targeted drug delivery system and how EVs can be incorporated into biomaterials to produce a personalized wound dressing. Finally, we discuss the status of clinically deploying EVs as a therapeutic agent in wound care.

Original languageEnglish (US)
Article number1543
JournalPharmaceutics
Volume13
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • Biomaterial
  • Chronic wound
  • Drug delivery
  • Extracellular vesicles
  • Mesenchymal stem cell
  • Wound healing

ASJC Scopus subject areas

  • Pharmaceutical Science

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