Extracellular Vesicles as Biomarkers and Therapeutics in Dermatology: A Focus on Exosomes

Jeffrey D. McBride, Luis Rodriguez-Menocal, Evangelos V. Badiavas

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circulation, and body fluids. Of these vesicles, exosomes are of growing interest among investigators across multiple fields, including dermatology. The characteristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstream functions are vastly different, depending on the cell origin. Here, we review concepts in extracellular vesicle biology, with a focus on exosomes, highlighting recent studies in the field of dermatology. Furthermore, we highlight emerging technical issues associated with isolating and measuring exosomes. Extracellular vesicles, including exosomes, have immediate potential for serving as biomarkers and therapeutics in dermatology over the next decade.

Original languageEnglish (US)
Pages (from-to)1622-1629
Number of pages8
JournalJournal of Investigative Dermatology
Volume137
Issue number8
DOIs
StatePublished - Aug 2017

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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