Abstract
Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circulation, and body fluids. Of these vesicles, exosomes are of growing interest among investigators across multiple fields, including dermatology. The characteristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstream functions are vastly different, depending on the cell origin. Here, we review concepts in extracellular vesicle biology, with a focus on exosomes, highlighting recent studies in the field of dermatology. Furthermore, we highlight emerging technical issues associated with isolating and measuring exosomes. Extracellular vesicles, including exosomes, have immediate potential for serving as biomarkers and therapeutics in dermatology over the next decade.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1622-1629 |
| Number of pages | 8 |
| Journal | Journal of Investigative Dermatology |
| Volume | 137 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2017 |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology
Cite this
Extracellular Vesicles as Biomarkers and Therapeutics in Dermatology : A Focus on Exosomes. / McBride, Jeffrey D.; Rodriguez-Menocal, Luis; Badiavas, Evangelos V.
In: Journal of Investigative Dermatology, Vol. 137, No. 8, 01.08.2017, p. 1622-1629.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Extracellular Vesicles as Biomarkers and Therapeutics in Dermatology
T2 - A Focus on Exosomes
AU - McBride, Jeffrey D.
AU - Rodriguez-Menocal, Luis
AU - Badiavas, Evangelos V
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circulation, and body fluids. Of these vesicles, exosomes are of growing interest among investigators across multiple fields, including dermatology. The characteristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstream functions are vastly different, depending on the cell origin. Here, we review concepts in extracellular vesicle biology, with a focus on exosomes, highlighting recent studies in the field of dermatology. Furthermore, we highlight emerging technical issues associated with isolating and measuring exosomes. Extracellular vesicles, including exosomes, have immediate potential for serving as biomarkers and therapeutics in dermatology over the next decade.
AB - Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circulation, and body fluids. Of these vesicles, exosomes are of growing interest among investigators across multiple fields, including dermatology. The characteristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstream functions are vastly different, depending on the cell origin. Here, we review concepts in extracellular vesicle biology, with a focus on exosomes, highlighting recent studies in the field of dermatology. Furthermore, we highlight emerging technical issues associated with isolating and measuring exosomes. Extracellular vesicles, including exosomes, have immediate potential for serving as biomarkers and therapeutics in dermatology over the next decade.
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UR - http://www.scopus.com/inward/citedby.url?scp=85024900460&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2017.04.021
DO - 10.1016/j.jid.2017.04.021
M3 - Review article
VL - 137
SP - 1622
EP - 1629
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 8
ER -