TY - JOUR
T1 - Extracellular Vesicles as Biomarkers and Therapeutics in Dermatology
T2 - A Focus on Exosomes
AU - McBride, Jeffrey D.
AU - Rodriguez-Menocal, Luis
AU - Badiavas, Evangelos V.
N1 - Publisher Copyright:
© 2017 The Authors
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2017/8
Y1 - 2017/8
N2 - Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circulation, and body fluids. Of these vesicles, exosomes are of growing interest among investigators across multiple fields, including dermatology. The characteristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstream functions are vastly different, depending on the cell origin. Here, we review concepts in extracellular vesicle biology, with a focus on exosomes, highlighting recent studies in the field of dermatology. Furthermore, we highlight emerging technical issues associated with isolating and measuring exosomes. Extracellular vesicles, including exosomes, have immediate potential for serving as biomarkers and therapeutics in dermatology over the next decade.
AB - Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circulation, and body fluids. Of these vesicles, exosomes are of growing interest among investigators across multiple fields, including dermatology. The characteristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstream functions are vastly different, depending on the cell origin. Here, we review concepts in extracellular vesicle biology, with a focus on exosomes, highlighting recent studies in the field of dermatology. Furthermore, we highlight emerging technical issues associated with isolating and measuring exosomes. Extracellular vesicles, including exosomes, have immediate potential for serving as biomarkers and therapeutics in dermatology over the next decade.
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U2 - 10.1016/j.jid.2017.04.021
DO - 10.1016/j.jid.2017.04.021
M3 - Review article
C2 - 28648952
AN - SCOPUS:85024900460
VL - 137
SP - 1622
EP - 1629
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 8
ER -