Extracellular matrix molecules in skin wound repair

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Wound microenvironment has been shown to be critical to the wound healing. Skin wound microenvironment is primarily composed of cells such as fibroblasts, endothelial cells, and matrix proteins such as collagen and laminin and other extracellular matrix (ECM) proteins, as well as cytokines/growth factors released as a result of injury and inflammation. The ECM proteins play important roles in wound healing processes by providing both scaffold support and signaling roles. During wound repair, ECM proteins promote cell adhesion and migration, and mediate the interactions between cells as well as cells and matrices. In addition, they serve as reservoir and modulator for growth factors. ECM binds cells through specific cell surface receptors, of which integrins are likely most important and best studied receptors. The expression and function of these ECM molecules and their receptors are highly regulated spatially and temporally during wound healing and tissue remodeling. In human skin, fibroblasts are the major source for ECM synthesis, however keratinocytes and endothelial cells also produce some of the ECM components, such as type IV and type VII collagens and laminins in basement membranes. Inappropriate deposition of ECM components impairs normal healing and function. In this chapter, we will discuss ECM components and their roles in wound repair.

Original languageEnglish (US)
Title of host publicationWound Healing
Subtitle of host publicationProcess, Phases and Promoting
PublisherNova Science Publishers, Inc.
Pages49-71
Number of pages23
ISBN (Print)9781612098470
StatePublished - Dec 1 2011

Keywords

  • Collagen
  • Extracellular matrix
  • Fibronectin
  • Growth factor
  • Integrin
  • Laminin
  • Matricellular proteins
  • Matrix metalloproteinases
  • SPARC
  • Tenascin
  • Thrombospondin 1 and 2
  • Vitronectin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Extracellular matrix molecules in skin wound repair'. Together they form a unique fingerprint.

  • Cite this

    Tang, L., Kirsner, R. S., & Li, J. (2011). Extracellular matrix molecules in skin wound repair. In Wound Healing: Process, Phases and Promoting (pp. 49-71). Nova Science Publishers, Inc..