Extracellular matrix in angiogenesis: Dynamic structures with translational potential

Sabine A. Eming, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function, vascular structures provide also a critical interface in the balance of tissue homoeostasis and immune functions. Therefore, understanding the biology of the vascular system is a challenging and important objective because it is vital to many physiological and pathological processes. Unravelling mechanisms of blood vessel expansion and remodelling would offer therapeutic options to ameliorate disorders that are currently leading causes of mortality and morbidity, including cardiovascular diseases, cancer, chronic inflammatory disorders, diabetic retinopathy, tissue defects caused by trauma or chronic skin ulcers. This article will review cellular and molecular mechanisms controlling angiogenesis in the light of recent reports and data from our own laboratories. We will focus on the interaction of growth factors with extracellular matrix (ECM) components during the formation of vascular structures in health and disease. Finally, this article will provide a rationale for targeting the ECM-morphogen interplay for therapeutic angiogenesis.

Original languageEnglish
Pages (from-to)605-613
Number of pages9
JournalExperimental Dermatology
Volume20
Issue number7
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

Fingerprint

Extracellular Matrix
Blood Vessels
Tissue homeostasis
Tissue
Blood vessels
Nutrients
Intercellular Signaling Peptides and Proteins
Skin
Health
Oxygen
Defects
Physiological Phenomena
Skin Ulcer
Systems Biology
Diabetic Retinopathy
Pathologic Processes
Homeostasis
Cardiovascular Diseases
Morbidity
Food

Keywords

  • Angiogenesis
  • Extracellular matrix
  • Tissue repair

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry

Cite this

Extracellular matrix in angiogenesis : Dynamic structures with translational potential. / Eming, Sabine A.; Hubbell, Jeffrey A.

In: Experimental Dermatology, Vol. 20, No. 7, 01.07.2011, p. 605-613.

Research output: Contribution to journalArticle

Eming, Sabine A. ; Hubbell, Jeffrey A. / Extracellular matrix in angiogenesis : Dynamic structures with translational potential. In: Experimental Dermatology. 2011 ; Vol. 20, No. 7. pp. 605-613.
@article{01412bdf3eac49d4b597ef5ba3cf6f9b,
title = "Extracellular matrix in angiogenesis: Dynamic structures with translational potential",
abstract = "The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function, vascular structures provide also a critical interface in the balance of tissue homoeostasis and immune functions. Therefore, understanding the biology of the vascular system is a challenging and important objective because it is vital to many physiological and pathological processes. Unravelling mechanisms of blood vessel expansion and remodelling would offer therapeutic options to ameliorate disorders that are currently leading causes of mortality and morbidity, including cardiovascular diseases, cancer, chronic inflammatory disorders, diabetic retinopathy, tissue defects caused by trauma or chronic skin ulcers. This article will review cellular and molecular mechanisms controlling angiogenesis in the light of recent reports and data from our own laboratories. We will focus on the interaction of growth factors with extracellular matrix (ECM) components during the formation of vascular structures in health and disease. Finally, this article will provide a rationale for targeting the ECM-morphogen interplay for therapeutic angiogenesis.",
keywords = "Angiogenesis, Extracellular matrix, Tissue repair",
author = "Eming, {Sabine A.} and Hubbell, {Jeffrey A.}",
year = "2011",
month = "7",
day = "1",
doi = "10.1111/j.1600-0625.2011.01309.x",
language = "English",
volume = "20",
pages = "605--613",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Extracellular matrix in angiogenesis

T2 - Dynamic structures with translational potential

AU - Eming, Sabine A.

AU - Hubbell, Jeffrey A.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function, vascular structures provide also a critical interface in the balance of tissue homoeostasis and immune functions. Therefore, understanding the biology of the vascular system is a challenging and important objective because it is vital to many physiological and pathological processes. Unravelling mechanisms of blood vessel expansion and remodelling would offer therapeutic options to ameliorate disorders that are currently leading causes of mortality and morbidity, including cardiovascular diseases, cancer, chronic inflammatory disorders, diabetic retinopathy, tissue defects caused by trauma or chronic skin ulcers. This article will review cellular and molecular mechanisms controlling angiogenesis in the light of recent reports and data from our own laboratories. We will focus on the interaction of growth factors with extracellular matrix (ECM) components during the formation of vascular structures in health and disease. Finally, this article will provide a rationale for targeting the ECM-morphogen interplay for therapeutic angiogenesis.

AB - The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function, vascular structures provide also a critical interface in the balance of tissue homoeostasis and immune functions. Therefore, understanding the biology of the vascular system is a challenging and important objective because it is vital to many physiological and pathological processes. Unravelling mechanisms of blood vessel expansion and remodelling would offer therapeutic options to ameliorate disorders that are currently leading causes of mortality and morbidity, including cardiovascular diseases, cancer, chronic inflammatory disorders, diabetic retinopathy, tissue defects caused by trauma or chronic skin ulcers. This article will review cellular and molecular mechanisms controlling angiogenesis in the light of recent reports and data from our own laboratories. We will focus on the interaction of growth factors with extracellular matrix (ECM) components during the formation of vascular structures in health and disease. Finally, this article will provide a rationale for targeting the ECM-morphogen interplay for therapeutic angiogenesis.

KW - Angiogenesis

KW - Extracellular matrix

KW - Tissue repair

UR - http://www.scopus.com/inward/record.url?scp=79959507521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959507521&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0625.2011.01309.x

DO - 10.1111/j.1600-0625.2011.01309.x

M3 - Article

C2 - 21692861

AN - SCOPUS:79959507521

VL - 20

SP - 605

EP - 613

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 7

ER -