Extracellular matrix components as therapeutics for spinal cord injury

Agnes E. Haggerty, Megan M. Marlow, Martin Oudega

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

There is no treatment for people with spinal cord injury that leads to significant functional improvements. The extracellular matrix is an intricate, 3-dimensional, structural framework that defines the environment for cells in the central nervous system. The components of extracellular matrix have signaling and regulatory roles in the fate and function of neuronal and non-neuronal cells in the central nervous system. This review discusses the therapeutic potential of extracellular matrix components for spinal cord repair.

Original languageEnglish (US)
JournalNeuroscience Letters
DOIs
StateAccepted/In press - Jul 16 2016

Fingerprint

Spinal Cord Injuries
Extracellular Matrix
Central Nervous System
Spinal Cord Regeneration
Therapeutics

Keywords

  • Axon growth
  • Central nervous system
  • Collagen
  • ECM
  • Fibronectin
  • Glial scar
  • Laminin
  • Transplantation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Extracellular matrix components as therapeutics for spinal cord injury. / Haggerty, Agnes E.; Marlow, Megan M.; Oudega, Martin.

In: Neuroscience Letters, 16.07.2016.

Research output: Contribution to journalArticle

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