Extracellular matrix binding mixed micelles for drug delivery applications

Conlin P. O'Neil, André J. van der Vlies, Diana Velluto, Christine Wandrey, Davide Demurtas, Jacques Dubochet, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

We present the formation of collagen-binding mixed micelles and their potential suitability to deliver therapeutic drugs to the vessel wall. We modified poly(ethylene oxide)-bl-poly(propylene oxide)-bl-poly(ethylene oxide) (Pluronic F-127) to display sulfate groups on the terminus of the PEO block to act as a heparin mimics and bind to collagen in the extracellular matrix. This functionalized macroamphiphile was incorporated into a mixed micelle with poly(propylene sulfide)-bl-poly(ethylene oxide), a macroamphiphile that demonstrates improved micellar stability relative to Pluronic F-127 micelles. The mixed micelles were examined using analytical ultracentrifugation, dynamic light scattering, transmission electron microscopy, and measures of the critical micellar concentration using surface tensiometry. Encapsulation and in vitro release of Sirolimus, an immunosuppressant drug of interest in coronary artery treatment, was considered as an example. Mixed micelles with the sulfate functionality demonstrated enhanced binding to collagen I coated surfaces, suggestive of the potential for binding to the extracellular milieu.

Original languageEnglish (US)
Pages (from-to)146-151
Number of pages6
JournalJournal of Controlled Release
Volume137
Issue number2
DOIs
StatePublished - Jul 20 2009

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Keywords

  • Block copolymers
  • Drug delivery
  • Extracellular matrix
  • Mixed micelles
  • Sirolimus

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

O'Neil, C. P., van der Vlies, A. J., Velluto, D., Wandrey, C., Demurtas, D., Dubochet, J., & Hubbell, J. A. (2009). Extracellular matrix binding mixed micelles for drug delivery applications. Journal of Controlled Release, 137(2), 146-151. https://doi.org/10.1016/j.jconrel.2009.03.013