Externally controlled on-demand release of anti-HIV drug using magneto-electric nanoparticles as carriers

Madhavan Nair, Rakesh Guduru, Ping Liang, Jeongmin Hong, Vidya Sagar, Sakhrat Khizroev

Research output: Contribution to journalArticlepeer-review

150 Scopus citations

Abstract

Although highly active anti-retroviral therapy has resulted in remarkable decline in the morbidity and mortality in AIDS patients, inadequately low delivery of anti-retroviral drugs across the blood-brain barrier results in virus persistence. The capability of high-efficacy-targeted drug delivery and on-demand release remains a formidable task. Here we report an in vitro study to demonstrate the on-demand release of azidothymidine 5′-triphosphate, an anti-human immunodeficiency virus drug, from 30 nm CoFe2O 4@BaTiO3 magneto-electric nanoparticles by applying a low alternating current magnetic field. Magneto-electric nanoparticles as field-controlled drug carriers offer a unique capability of field-triggered release after crossing the blood-brain barrier. Owing to the intrinsic magnetoelectricity, these nanoparticles can couple external magnetic fields with the electric forces in drug-carrier bonds to enable remotely controlled delivery without exploiting heat. Functional and structural integrity of the drug after the release was confirmed in in vitro experiments with human immunodeficiency virus-infected cells and through atomic force microscopy, spectrophotometry, Fourier transform infrared and mass spectrometry studies.

Original languageEnglish (US)
Article number1707
JournalNature communications
Volume4
DOIs
StatePublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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