Extensive genetic variability of simian immunodeficiency virus from African green monkeys

Y. Li, Y. M. Naidu, M. D. Daniel, Ronald Charles Desrosiers

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Serological surveys have revealed that 30 to 50% of wild-caught African green monkeys have antibodies reactive to simian immunodeficiency virus (SIV), a retrovirus related to human immunodeficiency virus (HIV). Although the nucleotide sequence of one SIVagm isolate, Tyo1, was recently reported, the extent of genetic variability among SIVagm isolates remains to be determined. Restriction endonuclease mapping of infectious molecular clones of two SIVagm isolates (266 and 385), described in this note, revealed conservation of only 4 of 39 sites across the genome. Partial sequence analysis of the molecular clones revealed only 80% amino acid sequence concervation in the pol gene. Although the three Kenyan SIVagm isolates, Tyol1, 385, and 266, are more closely related to each other than to other primate lentiviruses, genetic variation among these three isolates is much greater than that observed previously among individual HIV type 1 (HIV-1), HIV-2, or SIVmac isolates. Less variability among HIV-1 and HIV-2 isolates could be explained by recent entry into the human population. The extensive genetic variation in these Kenyan SIVagm isolates should prompt continued examination of SIVagm variability from dispersed geographic regions; SIVagm strains much more closely related to HIV-1, HIV-2, or SIVmac which would be reasonable candidates for recent cross-species transmission may be found.

Original languageEnglish (US)
Pages (from-to)1800-1802
Number of pages3
JournalJournal of Virology
Volume63
Issue number4
StatePublished - 1989
Externally publishedYes

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Human immunodeficiency virus 2
Simian immunodeficiency virus
Cercopithecus aethiops
Simian Immunodeficiency Virus
HIV-2
Human immunodeficiency virus 1
HIV-1
genetic variation
Retroviridae
Primate Lentiviruses
Clone Cells
pol Genes
clones
Restriction Mapping
Lentivirus
restriction mapping
Human immunodeficiency virus
serological surveys
human population
Sequence Analysis

ASJC Scopus subject areas

  • Immunology

Cite this

Extensive genetic variability of simian immunodeficiency virus from African green monkeys. / Li, Y.; Naidu, Y. M.; Daniel, M. D.; Desrosiers, Ronald Charles.

In: Journal of Virology, Vol. 63, No. 4, 1989, p. 1800-1802.

Research output: Contribution to journalArticle

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