Extended remission of a recurrent median nerve malignant peripheral nerve sheath tumor after multimodal treatment

Howard Landy, Lynn G Feun, Arnold Markoe, Sherri Patchen, Joy Bruce, Justin Marcus, Allan D Levi

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are difficult to control despite aggressive treatment. In this report the authors describe the treatment and follow-up review of a patient with neurofibromatosis Type 1 who harbored a recurrent median nerve MPNST. The man underwent preoperative intraarterial and intravenous chemotherapy followed by additional surgery for gross-total removal and postoperative radiotherapy. Two courses of preoperative intraarterial cisplatin and intravenous Adriamycin produced significant tumor shrinkage. Gross-total removal of the remaining tumor without amputation of the arm was followed by fractionated radiotherapy (total minimum tumor dose 6485 cGy, maximal dose 6575 cGy). The patient is alive 9.5 years after treatment without evidence of tumor recurrence and with only focal median nerve functional deficits. A review of the patient's treatment is warranted to provide a description of a regimen that may be useful in the treatment of similar patients in the future.

Original languageEnglish
Pages (from-to)760-763
Number of pages4
JournalJournal of Neurosurgery
Volume103
Issue number4
StatePublished - Oct 1 2005

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Peripheral Nervous System Neoplasms
Combined Modality Therapy
Median Nerve
Neurilemmoma
Neoplasms
Radiotherapy
Therapeutics
Neurofibromatosis 1
Amputation
Doxorubicin
Cisplatin
Recurrence
Drug Therapy

Keywords

  • Chemotherapy
  • Malignant peripheral nerve sheath tumor
  • Median nerve
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Extended remission of a recurrent median nerve malignant peripheral nerve sheath tumor after multimodal treatment. / Landy, Howard; Feun, Lynn G; Markoe, Arnold; Patchen, Sherri; Bruce, Joy; Marcus, Justin; Levi, Allan D.

In: Journal of Neurosurgery, Vol. 103, No. 4, 01.10.2005, p. 760-763.

Research output: Contribution to journal › Article

Landy, H, Feun, LG, Markoe, A, Patchen, S, Bruce, J, Marcus, J & Levi, AD 2005, 'Extended remission of a recurrent median nerve malignant peripheral nerve sheath tumor after multimodal treatment', Journal of Neurosurgery, vol. 103, no. 4, pp. 760-763.
Landy H, Feun LG, Markoe A, Patchen S, Bruce J, Marcus J et al. Extended remission of a recurrent median nerve malignant peripheral nerve sheath tumor after multimodal treatment. Journal of Neurosurgery. 2005 Oct 1;103(4):760-763.
Landy, Howard ; Feun, Lynn G ; Markoe, Arnold ; Patchen, Sherri ; Bruce, Joy ; Marcus, Justin ; Levi, Allan D. / Extended remission of a recurrent median nerve malignant peripheral nerve sheath tumor after multimodal treatment. In: Journal of Neurosurgery. 2005 ; Vol. 103, No. 4. pp. 760-763.
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