Expression profiling in the aging brain: A perspective

James E. Galvin, Stephen D. Ginsberg

Research output: Contribution to journalShort surveypeer-review

29 Scopus citations

Abstract

To evaluate molecular events associated with the aging process in animal models and human tissues, microarray analysis is performed at the regional and cellular levels to define transcriptional patterns or mosaics that may lead to better understanding of the mechanism(s) that drive senescence. In this review, we outline the experimental and analytical issues associated with high-throughput genomic analyses in aging brain and other tissues for a comprehensive evaluation of the current state of microarray analysis in aging paradigms. Ultimately, the goal of these studies is to apply functional genomics and proteomics approaches to aging research to develop new tools to assess age in cell- and tissue-specific manners in order to develop aging biomarkers for pharmacotherapeutic interventions and disease prevention.

Original languageEnglish (US)
Pages (from-to)529-547
Number of pages19
JournalAgeing Research Reviews
Volume4
Issue number4
DOIs
StatePublished - Nov 2005
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Functional genomics
  • Gene expression
  • Microarray
  • Senescence
  • Single cell profiling

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

Fingerprint

Dive into the research topics of 'Expression profiling in the aging brain: A perspective'. Together they form a unique fingerprint.

Cite this