Expression profiling for bladder cancer: Strategies to uncover prognostic factors

Georg Bartsch, Anirban P. Mitra, Richard J. Cote

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Despite being a common cancer worldwide, management of transitional cell carcinoma of the bladder currently relies primarily on clinical staging and histopathologic parameters. Assaying alterations in molecular pathways can contribute valuable information that can accurately predict outcome and chemotherapeutic response in individual patients with bladder cancer. Medium-to high-throughput gene-expression profiling technologies are now allowing multiplexed assessment of alterations responsible for the genesis and progression of bladder tumors. These investigations employ global or pathway-based approaches to define molecular signatures that can predict prognosis independent of traditional clinical performance metrics. Prognostic panels generated using these strategies can also elucidate the biology of tumor progression and identify potential therapeutic targets.

Original languageEnglish (US)
Pages (from-to)1945-1954
Number of pages10
JournalExpert review of anticancer therapy
Volume10
Issue number12
DOIs
StatePublished - Dec 2010

Keywords

  • gene-expression profiling
  • global approach
  • microarray
  • multimarker analysis
  • pathway-specific approach
  • urothelial carcinoma

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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