Expression profiling and pharmacotherapeutic development in the central nervous system

James E. Galvin, Stephen D. Ginsberg

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Expression profiling data is available for many diverse tissues throughout the body, allowing for exciting hypothesis testing of critical concepts such as cellular development, differentiation, normative function, and disease pathogenesis. The central nervous system is an ideal structure to evaluate relationships between functional genomics and expression data. Recent developments in gene array technologies, specifically cDNA microarray platforms, have made it easier to try to understand the multiplicity of gene alterations that occur within the brains of animal models and postmortem human tissues. However, unlike structures have one principal cell type, the brain contains diverse populations of phenotypically distinct cell types. A goal of modern molecular and cellular neuroscience is to assay gene expression from homogeneous populations of cells within a defined region without potential contamination by expression profiles of adjacent neuronal subtypes and non-neuronal cells. This is a difficult task that demands a multidisciplinary approach that is highlighted in this review within the context of neurodegenerative pathology.

Original languageEnglish (US)
Pages (from-to)264-269
Number of pages6
JournalAlzheimer disease and associated disorders
Volume18
Issue number4
StatePublished - Oct 2004
Externally publishedYes

Keywords

  • And single-cell analysis
  • CDNA microarray
  • Dementia
  • Pharmacogenomics
  • Postmortem human brain
  • RNA amplification

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'Expression profiling and pharmacotherapeutic development in the central nervous system'. Together they form a unique fingerprint.

Cite this