Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells

Stephen Dewhurst, Mario Stevenson, David J. Volsky

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Three human cell lines of astrocytic origin were evaluated for expression of a human T-lymphocyte surface glycoprotein, T4, which also serves as a cellular receptor for the human immunodeficiency virus (AIDS virus, HIV). T4 antigen was detected on the cell surface of 2 of these cell lines using monoclonal OKT-4 antibody and flow cytometry. Gene transcripts encoding the T4 molecule were detected by a ribonuclease protection assay in surface T4-positive and -negative cells. Our results suggest that astrocytes may serve as targets for HIV infection in the brain.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalFEBS letters
Volume213
Issue number1
DOIs
StatePublished - Mar 9 1987
Externally publishedYes

Keywords

  • AIDS
  • Astrocyte
  • Glial fibrillary acidic protein
  • HIV receptor
  • Human immunodeficiency virus (HIV)
  • T4 antigen

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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