Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells

Stephen Dewhurst, Mario Stevenson, David J. Volsky

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Three human cell lines of astrocytic origin were evaluated for expression of a human T-lymphocyte surface glycoprotein, T4, which also serves as a cellular receptor for the human immunodeficiency virus (AIDS virus, HIV). T4 antigen was detected on the cell surface of 2 of these cell lines using monoclonal OKT-4 antibody and flow cytometry. Gene transcripts encoding the T4 molecule were detected by a ribonuclease protection assay in surface T4-positive and -negative cells. Our results suggest that astrocytes may serve as targets for HIV infection in the brain.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalFEBS Letters
Volume213
Issue number1
DOIs
StatePublished - Mar 9 1987
Externally publishedYes

Fingerprint

HIV Receptors
Viruses
Brain
Cells
HIV
Molecules
Gene encoding
T-cells
Flow cytometry
Membrane Glycoproteins
Ribonucleases
Cell Line
Assays
Antigens
Astrocytes
HIV Infections
Antibodies
Flow Cytometry
T-Lymphocytes
Genes

Keywords

  • AIDS
  • Astrocyte
  • Glial fibrillary acidic protein
  • HIV receptor
  • Human immunodeficiency virus (HIV)
  • T4 antigen

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells. / Dewhurst, Stephen; Stevenson, Mario; Volsky, David J.

In: FEBS Letters, Vol. 213, No. 1, 09.03.1987, p. 133-137.

Research output: Contribution to journalArticle

Dewhurst, Stephen ; Stevenson, Mario ; Volsky, David J. / Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells. In: FEBS Letters. 1987 ; Vol. 213, No. 1. pp. 133-137.
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