Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication

Bianca R. Mothé, Jason Weinfurter, Chenxi Wang, William Rehrauer, Nancy Wilson, Todd M. Allen, David B. Allison, David I. Watkins

Research output: Contribution to journalArticle

168 Scopus citations

Abstract

Several HLA alleles are associated with attenuated human immunodeficiency virus disease progression. We explored the relationship between the expression of particular major histocompatibility complex (MHC) class I alleles and viremia in simian immunodeficiency virus SIVmac239-infected macaques. Of the common MHC class I alleles, animals that expressed Mamu-A*01 exhibited the best control of viral replication.

Original languageEnglish (US)
Pages (from-to)2736-2740
Number of pages5
JournalJournal of virology
Volume77
Issue number4
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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