TY - JOUR
T1 - Expression of the inflammatory chemokines CCL2, CCL5 and CXCL2 and the receptors CCR1-3 and CXCR2 in T lymphocytes from mammary tumor-bearing mice
AU - Owen, Jennifer L.
AU - Criscitiello, Michael F.
AU - Libreros, Stephania
AU - Garcia-Areas, Ramon
AU - Guthrie, Kathleen
AU - Torroella-Kouri, Marta
AU - Iragavarapu-Charyulu, Vijaya
N1 - Funding Information:
This work was supported by grant F02S-FAU-1 from the Florida division of the American Cancer Society and NIH R15 CA135513-01 and R15 CA135513-01-OS1 .
PY - 2011
Y1 - 2011
N2 - Chemokines and their receptors have been studied in several solid tumor models as mediators of inflammation. In turn, inflammation has been implicated in the promotion and progression of tumors, and as such, chemokines have been proposed as novel molecular targets for chemotherapy. While the expression of these molecules has been described in tumor cells, endothelial cells, macrophages and neutrophils, less attention has been paid to the expression profile of these molecules by T lymphocytes in the periphery or infiltrating the tumor. Using the D1-DMBA-3 murine mammary adenocarcinoma model, we aimed to better characterize the differential expression of chemokines and/or their receptors in the host and in the tumor microenvironment, and specifically, in the T cells of tumor-bearing mice compared to normal control animals. We found that T lymphocytes from tumor-bearing mice express the pro-inflammatory chemokines, CCL2, CCL5 and CXCL2, as well as the chemokine receptors, CCR1, CCR2, CCR3 and CXCR2.
AB - Chemokines and their receptors have been studied in several solid tumor models as mediators of inflammation. In turn, inflammation has been implicated in the promotion and progression of tumors, and as such, chemokines have been proposed as novel molecular targets for chemotherapy. While the expression of these molecules has been described in tumor cells, endothelial cells, macrophages and neutrophils, less attention has been paid to the expression profile of these molecules by T lymphocytes in the periphery or infiltrating the tumor. Using the D1-DMBA-3 murine mammary adenocarcinoma model, we aimed to better characterize the differential expression of chemokines and/or their receptors in the host and in the tumor microenvironment, and specifically, in the T cells of tumor-bearing mice compared to normal control animals. We found that T lymphocytes from tumor-bearing mice express the pro-inflammatory chemokines, CCL2, CCL5 and CXCL2, as well as the chemokine receptors, CCR1, CCR2, CCR3 and CXCR2.
KW - Angiogenesis
KW - Chemokine receptors
KW - Chemokines
KW - Mammary tumor
KW - T lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=80955179527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80955179527&partnerID=8YFLogxK
U2 - 10.1016/j.cellimm.2011.05.004
DO - 10.1016/j.cellimm.2011.05.004
M3 - Article
C2 - 21621198
AN - SCOPUS:80955179527
VL - 270
SP - 172
EP - 182
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 2
ER -