Abstract
Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.
Original language | English (US) |
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Pages (from-to) | 69-72 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 141 |
Issue number | 1 |
DOIs | |
State | Published - Apr 2008 |
Keywords
- B-cells
- Diffuse large B-cell lymphoma
- Human germinal-centre-associated protein
- Lymphoma
- Rheumatoid arthritis
ASJC Scopus subject areas
- Hematology