Abstract
Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.
| Original language | English |
|---|---|
| Pages (from-to) | 69-72 |
| Number of pages | 4 |
| Journal | British Journal of Haematology |
| Volume | 141 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1 2008 |
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Keywords
- B-cells
- Diffuse large B-cell lymphoma
- Human germinal-centre-associated protein
- Lymphoma
- Rheumatoid arthritis
ASJC Scopus subject areas
- Hematology
Cite this
Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis. / Baecklund, Eva; Natkunam, Yasodha; Backlin, Carin; Iliadou, Anastasia; Askling, Johan; Ekbom, Anders; Feltelius, Nils; Klareskog, Lars; Enblad, Gunilla; Lossos, Izidore; Levy, Ronald; Sundström, Christer; Rosenquist, Richard.
In: British Journal of Haematology, Vol. 141, No. 1, 01.04.2008, p. 69-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis
AU - Baecklund, Eva
AU - Natkunam, Yasodha
AU - Backlin, Carin
AU - Iliadou, Anastasia
AU - Askling, Johan
AU - Ekbom, Anders
AU - Feltelius, Nils
AU - Klareskog, Lars
AU - Enblad, Gunilla
AU - Lossos, Izidore
AU - Levy, Ronald
AU - Sundström, Christer
AU - Rosenquist, Richard
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.
AB - Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.
KW - B-cells
KW - Diffuse large B-cell lymphoma
KW - Human germinal-centre-associated protein
KW - Lymphoma
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=40449110250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40449110250&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.2008.07011.x
DO - 10.1111/j.1365-2141.2008.07011.x
M3 - Article
C2 - 18324968
AN - SCOPUS:40449110250
VL - 141
SP - 69
EP - 72
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -