Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis

Eva Baecklund, Yasodha Natkunam, Carin Backlin, Anastasia Iliadou, Johan Askling, Anders Ekbom, Nils Feltelius, Lars Klareskog, Gunilla Enblad, Izidore S. Lossos, Ronald Levy, Christer Sundström, Richard Rosenquist

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalBritish Journal of Haematology
Volume141
Issue number1
DOIs
StatePublished - Apr 1 2008

Keywords

  • B-cells
  • Diffuse large B-cell lymphoma
  • Human germinal-centre-associated protein
  • Lymphoma
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Hematology

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    Baecklund, E., Natkunam, Y., Backlin, C., Iliadou, A., Askling, J., Ekbom, A., Feltelius, N., Klareskog, L., Enblad, G., Lossos, I. S., Levy, R., Sundström, C., & Rosenquist, R. (2008). Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis. British Journal of Haematology, 141(1), 69-72. https://doi.org/10.1111/j.1365-2141.2008.07011.x