Expression of receptor tyrosine phosphatases during development of the retinotectal projection of the chick

Matthias M. Ledig, Iain W. McKinnell, Thomas Mrsic-Flogel, Jun Wang, Caroline Alvares, Ivor Mason, John L. Bixby, Bernhard K. Mueller, Andrew W. Stoker

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Receptor tyrosine kinases and receptor protein tyrosine phosphatases (RPTPs) appear to coordinate many aspects of neural development, including axon growth and guidance. Here, we focus on the possible roles of RPTPs in the developing avian retinotectal system. Using both in situ hybridization analysis and immunohistochemistry, we show for the first time that five RPTP genes - CRYPα, CRYP-2, PTPμ, PTPγ, and PTPα - have different but overlapping expression patterns throughout the retina and the tectum. PTPα is restricted to Muller gila cells and radial gila of the tectum, indicating a possible function in controlling neuronal migration. PTPγ expression is restricted to amacrine neurons. CRYPα and CRYP-2 mRNAs in contrast are expressed throughout the retinal ganglion cell layer from where axons grow out to their tectal targets. PTPμ is expressed in a subset of these ganglion cells. CRYPα, CRYP-2, and PTPμ proteins are also localized in growth cones of retinal ganglion cell axons and are present in defined laminae of the tectum. Thus, the spatial and temporal expression of three distinct RPTP subtypes - CRYPα, CRYP-2, and PTPμ - are consistent with the possibility of their involvement in axon growth and guidance of the retinotectal projection.

Original languageEnglish (US)
Pages (from-to)81-96
Number of pages16
JournalJournal of Neurobiology
Issue number1
StatePublished - 1999


  • Axon guidance
  • Chicken
  • Optic tectum
  • Receptor protein tyrosine phosphatase
  • Retinal ganglion cells
  • Retinotectal projection

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Expression of receptor tyrosine phosphatases during development of the retinotectal projection of the chick'. Together they form a unique fingerprint.

Cite this