Expression of pannexin family of proteins in the retina

Galina Dvoriantchikova, Dmitry Ivanov, Yuri Panchin, Valery I. Shestopalov

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Expression of the Panx1 and Panx2 members of the pannexin family of gap junction proteins was studied in the retina by in situ hybridization and qRT-PCR. Both pannexins showed robust expression across the retina with predominant accumulation in the retinal ganglion cells (RGCs). In concordance, immunohistochemical analysis showed accumulation of the Panx1 protein in RGCs, amacrine, horizontal cells and their processes. Two Panx1 isoforms were detected: a ubiquitously expressed 58 kDa protein, and a 43 kDa isoform that specifically accumulated in the retina and brain. Our results indicated that Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons via the secondary messengers.

Original languageEnglish (US)
Pages (from-to)2178-2182
Number of pages5
JournalFEBS letters
Volume580
Issue number9
DOIs
StatePublished - Apr 17 2006

Keywords

  • Antibody
  • Gap junction proteins
  • Gene expression
  • Pannexin family
  • Retina
  • Retinal ganglion cells

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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