Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia

R. R. Tubbs, R. A. Savage, R. H. Crabtree, B. A. Sebek, R. Valenzuela, S. P. Benjamin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia. Am. J. Clin. Pathol 72:789-794, 1979. The diagnosis of malignant histiocytosis is usually based upon typical light microscopic features of the neoplasm. Supplementary cytochemical and immunologic features have been suggested as typical of malignant histiocytosis. The present study was prompted by an unusual erythropagocytic hepatocellular carcinoma having immunologic and cytochemical markers suggesting mononuclear phagocytic origin. Twenty-four neoplasms of unquestionable epithelial origin were prospectively evaluated for activity of alpha-naphthyl acetate esterase, a cytochemical marker useful in distinguishing between the non-Hodgkin's lymphomas and malignant histiocytosis. The epithelial tumors represented a broad spectrum of tissue origins and consistently demonstrated alpha-naphthyl acetate esterase activity. Thus, erythrophagocytosis and alpha-naphthyl acetate esterase positivity may be misleading in the unusual instance in which the histopathologic differential diagnosis includes malignant histiocytosis and epithelial neoplasia. Ultrastructural assessment is useful in the exclusion of poorly differentiated carcinoma.

Original languageEnglish
Pages (from-to)789-794
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume72
Issue number5
StatePublished - Dec 1 1979
Externally publishedYes

Fingerprint

Histiocytic Sarcoma
Naphthol AS D Esterase
Neoplasms
Glandular and Epithelial Neoplasms
Non-Hodgkin's Lymphoma
Hepatocellular Carcinoma
Differential Diagnosis
Biomarkers
Carcinoma
Light

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tubbs, R. R., Savage, R. A., Crabtree, R. H., Sebek, B. A., Valenzuela, R., & Benjamin, S. P. (1979). Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia. American Journal of Clinical Pathology, 72(5), 789-794.

Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia. / Tubbs, R. R.; Savage, R. A.; Crabtree, R. H.; Sebek, B. A.; Valenzuela, R.; Benjamin, S. P.

In: American Journal of Clinical Pathology, Vol. 72, No. 5, 01.12.1979, p. 789-794.

Research output: Contribution to journalArticle

Tubbs, RR, Savage, RA, Crabtree, RH, Sebek, BA, Valenzuela, R & Benjamin, SP 1979, 'Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia', American Journal of Clinical Pathology, vol. 72, no. 5, pp. 789-794.
Tubbs RR, Savage RA, Crabtree RH, Sebek BA, Valenzuela R, Benjamin SP. Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia. American Journal of Clinical Pathology. 1979 Dec 1;72(5):789-794.
Tubbs, R. R. ; Savage, R. A. ; Crabtree, R. H. ; Sebek, B. A. ; Valenzuela, R. ; Benjamin, S. P. / Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia. In: American Journal of Clinical Pathology. 1979 ; Vol. 72, No. 5. pp. 789-794.
@article{41f7b2419db14fb6a8012014c8cde8a4,
title = "Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia",
abstract = "Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia. Am. J. Clin. Pathol 72:789-794, 1979. The diagnosis of malignant histiocytosis is usually based upon typical light microscopic features of the neoplasm. Supplementary cytochemical and immunologic features have been suggested as typical of malignant histiocytosis. The present study was prompted by an unusual erythropagocytic hepatocellular carcinoma having immunologic and cytochemical markers suggesting mononuclear phagocytic origin. Twenty-four neoplasms of unquestionable epithelial origin were prospectively evaluated for activity of alpha-naphthyl acetate esterase, a cytochemical marker useful in distinguishing between the non-Hodgkin's lymphomas and malignant histiocytosis. The epithelial tumors represented a broad spectrum of tissue origins and consistently demonstrated alpha-naphthyl acetate esterase activity. Thus, erythrophagocytosis and alpha-naphthyl acetate esterase positivity may be misleading in the unusual instance in which the histopathologic differential diagnosis includes malignant histiocytosis and epithelial neoplasia. Ultrastructural assessment is useful in the exclusion of poorly differentiated carcinoma.",
author = "Tubbs, {R. R.} and Savage, {R. A.} and Crabtree, {R. H.} and Sebek, {B. A.} and R. Valenzuela and Benjamin, {S. P.}",
year = "1979",
month = "12",
day = "1",
language = "English",
volume = "72",
pages = "789--794",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "5",

}

TY - JOUR

T1 - Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia

AU - Tubbs, R. R.

AU - Savage, R. A.

AU - Crabtree, R. H.

AU - Sebek, B. A.

AU - Valenzuela, R.

AU - Benjamin, S. P.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia. Am. J. Clin. Pathol 72:789-794, 1979. The diagnosis of malignant histiocytosis is usually based upon typical light microscopic features of the neoplasm. Supplementary cytochemical and immunologic features have been suggested as typical of malignant histiocytosis. The present study was prompted by an unusual erythropagocytic hepatocellular carcinoma having immunologic and cytochemical markers suggesting mononuclear phagocytic origin. Twenty-four neoplasms of unquestionable epithelial origin were prospectively evaluated for activity of alpha-naphthyl acetate esterase, a cytochemical marker useful in distinguishing between the non-Hodgkin's lymphomas and malignant histiocytosis. The epithelial tumors represented a broad spectrum of tissue origins and consistently demonstrated alpha-naphthyl acetate esterase activity. Thus, erythrophagocytosis and alpha-naphthyl acetate esterase positivity may be misleading in the unusual instance in which the histopathologic differential diagnosis includes malignant histiocytosis and epithelial neoplasia. Ultrastructural assessment is useful in the exclusion of poorly differentiated carcinoma.

AB - Expression of monocytic-histiocytic cytochemical markers in epithelial neoplasia. Am. J. Clin. Pathol 72:789-794, 1979. The diagnosis of malignant histiocytosis is usually based upon typical light microscopic features of the neoplasm. Supplementary cytochemical and immunologic features have been suggested as typical of malignant histiocytosis. The present study was prompted by an unusual erythropagocytic hepatocellular carcinoma having immunologic and cytochemical markers suggesting mononuclear phagocytic origin. Twenty-four neoplasms of unquestionable epithelial origin were prospectively evaluated for activity of alpha-naphthyl acetate esterase, a cytochemical marker useful in distinguishing between the non-Hodgkin's lymphomas and malignant histiocytosis. The epithelial tumors represented a broad spectrum of tissue origins and consistently demonstrated alpha-naphthyl acetate esterase activity. Thus, erythrophagocytosis and alpha-naphthyl acetate esterase positivity may be misleading in the unusual instance in which the histopathologic differential diagnosis includes malignant histiocytosis and epithelial neoplasia. Ultrastructural assessment is useful in the exclusion of poorly differentiated carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0018595546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018595546&partnerID=8YFLogxK

M3 - Article

C2 - 228545

AN - SCOPUS:0018595546

VL - 72

SP - 789

EP - 794

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 5

ER -