Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting β-cell line, HIT T15

Frances M. Ashcroft, S. J H Ashcroft, P. O. Berggren, C. Betzholz, P. Rorsman, G. Trube, M. Welsh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Two types of exogenous K channel were identified in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting cell line HIT T15. One of these was the ATP-regulated K channel (G channel) as evidenced by its conductance and inhibition by tolbutamide. The other resembled the Ca-activated K channel from β-cells.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalFEBS Letters
Volume239
Issue number2
DOIs
StatePublished - Nov 7 1988
Externally publishedYes

Fingerprint

Tolbutamide
Xenopus laevis
Insulin-Secreting Cells
Oocytes
Adenosine Triphosphate
Cells
Insulin
Cell Line
Messenger RNA

Keywords

  • (Pancreatic β-cell)
  • ATP-sensitive K channel
  • K channel

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Ashcroft, F. M., Ashcroft, S. J. H., Berggren, P. O., Betzholz, C., Rorsman, P., Trube, G., & Welsh, M. (1988). Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting β-cell line, HIT T15. FEBS Letters, 239(2), 185-189. https://doi.org/10.1016/0014-5793(88)80913-X

Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting β-cell line, HIT T15. / Ashcroft, Frances M.; Ashcroft, S. J H; Berggren, P. O.; Betzholz, C.; Rorsman, P.; Trube, G.; Welsh, M.

In: FEBS Letters, Vol. 239, No. 2, 07.11.1988, p. 185-189.

Research output: Contribution to journalArticle

Ashcroft, FM, Ashcroft, SJH, Berggren, PO, Betzholz, C, Rorsman, P, Trube, G & Welsh, M 1988, 'Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting β-cell line, HIT T15', FEBS Letters, vol. 239, no. 2, pp. 185-189. https://doi.org/10.1016/0014-5793(88)80913-X
Ashcroft, Frances M. ; Ashcroft, S. J H ; Berggren, P. O. ; Betzholz, C. ; Rorsman, P. ; Trube, G. ; Welsh, M. / Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting β-cell line, HIT T15. In: FEBS Letters. 1988 ; Vol. 239, No. 2. pp. 185-189.
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