Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting β-cell line, HIT T15

Frances M. Ashcroft, S. J.H. Ashcroft, P. O. Berggren, C. Betzholz, P. Rorsman, G. Trube, M. Welsh

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Two types of exogenous K channel were identified in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting cell line HIT T15. One of these was the ATP-regulated K channel (G channel) as evidenced by its conductance and inhibition by tolbutamide. The other resembled the Ca-activated K channel from β-cells.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalFEBS letters
Volume239
Issue number2
DOIs
StatePublished - Nov 7 1988

Keywords

  • (Pancreatic β-cell)
  • ATP-sensitive K channel
  • K channel

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Fingerprint Dive into the research topics of 'Expression of K channels in Xenopus laevis oocytes injected with poly(A<sup>+</sup>) mRNA from the insulin-secreting β-cell line, HIT T15'. Together they form a unique fingerprint.

  • Cite this

    Ashcroft, F. M., Ashcroft, S. J. H., Berggren, P. O., Betzholz, C., Rorsman, P., Trube, G., & Welsh, M. (1988). Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting β-cell line, HIT T15. FEBS letters, 239(2), 185-189. https://doi.org/10.1016/0014-5793(88)80913-X