Expression of insulin-like growth factor-II mRNA in fetal kidney and Wilms' tumor. An in situ hybridization study

S. Paik, N. Rosen, W. Jung, J. M. You, M. E. Lippman, J. F. Perdue, D. Yee

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The pattern of insulin-like growth factor II (IGF-II) mRNA expression in developing kidney and Wilms' tumor was examined with in situ hybridization. In developing kidney, IGF-II was primarily expressed in blastemal cells and lost with their differentiation. In triphasic Wilms' tumor, a similar relationship was found. But in a monomorphous Wilms', tumor cells with epithelial differentiation expressed IGF-II mRNA. These data suggest that IGF-II may be involved in fetal nephrogenesis, that its expression is inversely coupled to normal epithelial differentiation, and that this differentiation may be aberrantly regulated in Wilms' tumor.

Original languageEnglish (US)
Pages (from-to)522-526
Number of pages5
JournalLaboratory Investigation
Volume61
Issue number5
StatePublished - Jan 1 1989

Keywords

  • Epithelial differentiation
  • Nephrogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Paik, S., Rosen, N., Jung, W., You, J. M., Lippman, M. E., Perdue, J. F., & Yee, D. (1989). Expression of insulin-like growth factor-II mRNA in fetal kidney and Wilms' tumor. An in situ hybridization study. Laboratory Investigation, 61(5), 522-526.