Abstract
RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1133-1138 |
| Number of pages | 6 |
| Journal | Neurochemical Research |
| Volume | 23 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 8 1998 |
Keywords
- Cochlea
- Growth factors
- Organ of corti
- Spiral ganglion
- Stria vascularis
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry
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Cite this
Malgrange, B., Rogister, B., Lefebvre, P. P., Mazy-Servais, C., Welcher, A. A., Bonnet, C., Hsu, R. Y., Rigo, J. M., Van De Water, T. R., & Moonen, G. (1998). Expression of growth factors and their receptors in the postnatal rat cochlea. Neurochemical Research, 23(8), 1133-1138. https://doi.org/10.1023/A:1020724506337