Abstract
RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells.
Original language | English (US) |
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Pages (from-to) | 1133-1138 |
Number of pages | 6 |
Journal | Neurochemical Research |
Volume | 23 |
Issue number | 8 |
DOIs | |
State | Published - Aug 8 1998 |
Keywords
- Cochlea
- Growth factors
- Organ of corti
- Spiral ganglion
- Stria vascularis
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry