Expression of growth factors and their receptors in the postnatal rat cochlea

Brigitte Malgrange; Bernard Rogister; Philippe P. Lefebvre; Cécile Mazy-Servais; Andrew A. Welcher; Christophe Bonnet; Rou Yin Hsu; Jean Michel Rigo; Thomas R. Van De Water; Gustave Moonen

doi:10.1023/A:1020724506337

Expression of growth factors and their receptors in the postnatal rat cochlea

Brigitte Malgrange, Bernard Rogister, Philippe P. Lefebvre, Cécile Mazy-Servais, Andrew A. Welcher, Christophe Bonnet, Rou Yin Hsu, Jean Michel Rigo, Thomas R. Van De Water, Gustave Moonen

Otolaryngology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells.

Original language	English (US)
Pages (from-to)	1133-1138
Number of pages	6
Journal	Neurochemical Research
Volume	23
Issue number	8
DOIs	https://doi.org/10.1023/A:1020724506337
State	Published - 1998

Keywords

Cochlea
Growth factors
Organ of corti
Spiral ganglion
Stria vascularis

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry

Access to Document

10.1023/A:1020724506337

Cite this

Expression of growth factors and their receptors in the postnatal rat cochlea. / Malgrange, Brigitte; Rogister, Bernard; Lefebvre, Philippe P.; Mazy-Servais, Cécile; Welcher, Andrew A.; Bonnet, Christophe; Hsu, Rou Yin; Rigo, Jean Michel; Van De Water, Thomas R.; Moonen, Gustave.

In: Neurochemical Research, Vol. 23, No. 8, 1998, p. 1133-1138.

Research output: Contribution to journal › Article › peer-review

@article{9da1f6f9b84c47bc9a9d0aea91a00f56,

title = "Expression of growth factors and their receptors in the postnatal rat cochlea",

abstract = "RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells.",

keywords = "Cochlea, Growth factors, Organ of corti, Spiral ganglion, Stria vascularis",

author = "Brigitte Malgrange and Bernard Rogister and Lefebvre, {Philippe P.} and C{\'e}cile Mazy-Servais and Welcher, {Andrew A.} and Christophe Bonnet and Hsu, {Rou Yin} and Rigo, {Jean Michel} and {Van De Water}, {Thomas R.} and Gustave Moonen",

note = "Funding Information: B. Malgrange and B. Rogister are, respectively, Research associate and Senior Research Assistant of the National Fund for Scientific Research (Belgium). This work was supported by grants from the National Fund for Scientific Research of Belgium, the Concerted Action of the Government of the French Community of Belgium, the Queen Elisabeth Medical Foundation of Belgium, and the Hearing Research Fund of the Montefiore Medical Center (USA). We thank P. Ernst for her technical assistance. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "1998",

doi = "10.1023/A:1020724506337",

language = "English (US)",

volume = "23",

pages = "1133--1138",

journal = "Neurochemical Research",

issn = "0364-3190",

publisher = "Springer New York",

number = "8",

}

TY - JOUR

T1 - Expression of growth factors and their receptors in the postnatal rat cochlea

AU - Malgrange, Brigitte

AU - Rogister, Bernard

AU - Lefebvre, Philippe P.

AU - Mazy-Servais, Cécile

AU - Welcher, Andrew A.

AU - Bonnet, Christophe

AU - Hsu, Rou Yin

AU - Rigo, Jean Michel

AU - Van De Water, Thomas R.

AU - Moonen, Gustave

N1 - Funding Information: B. Malgrange and B. Rogister are, respectively, Research associate and Senior Research Assistant of the National Fund for Scientific Research (Belgium). This work was supported by grants from the National Fund for Scientific Research of Belgium, the Concerted Action of the Government of the French Community of Belgium, the Queen Elisabeth Medical Foundation of Belgium, and the Hearing Research Fund of the Montefiore Medical Center (USA). We thank P. Ernst for her technical assistance. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1998

Y1 - 1998

N2 - RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells.

AB - RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells.

KW - Cochlea

KW - Growth factors

KW - Organ of corti

KW - Spiral ganglion

KW - Stria vascularis

UR - http://www.scopus.com/inward/record.url?scp=7344241528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7344241528&partnerID=8YFLogxK

U2 - 10.1023/A:1020724506337

DO - 10.1023/A:1020724506337

M3 - Article

C2 - 9704604

AN - SCOPUS:7344241528

VL - 23

SP - 1133

EP - 1138

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 8

ER -

Expression of growth factors and their receptors in the postnatal rat cochlea

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this