Expression of growth factors and their receptors in the postnatal rat cochlea

Brigitte Malgrange, Bernard Rogister, Philippe P. Lefebvre, Cécile Mazy-Servais, Andrew A. Welcher, Christophe Bonnet, Rou Yin Hsu, Jean Michel Rigo, Thomas R. Van De Water, Gustave Moonen

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells.

Original languageEnglish (US)
Pages (from-to)1133-1138
Number of pages6
JournalNeurochemical Research
Volume23
Issue number8
DOIs
StatePublished - Aug 8 1998

Keywords

  • Cochlea
  • Growth factors
  • Organ of corti
  • Spiral ganglion
  • Stria vascularis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

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    Malgrange, B., Rogister, B., Lefebvre, P. P., Mazy-Servais, C., Welcher, A. A., Bonnet, C., Hsu, R. Y., Rigo, J. M., Van De Water, T. R., & Moonen, G. (1998). Expression of growth factors and their receptors in the postnatal rat cochlea. Neurochemical Research, 23(8), 1133-1138. https://doi.org/10.1023/A:1020724506337