Expression of galectin-1 and -3 and of accessible binding sites during murine hair cycle

Uwe Wollina, D. Lange, Ralf Paus, M. Burchert, H. J. Gabius

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Although protein-carbohydrate interactions are supposed to play key roles in cell adhesion, signalling and growth control. Their exact role in skin physiology has only recently been investigated. The endogenous lectins galectin-1 and galectin-3 have been identified in skin including hair follicles. Here, we analyzed the expression and distribution of these galectins and their binding sites in C57BL/6 mice during hair cycle. The expression of galectin-1 and galectin-3 binding sites was found to be predominantly hair cycle-dependent showing some overlapping to the expression of galectin-1 and -3. The outer root sheath (ORS) expressed galectin-1 binding sites during anagen IV to VI and in early catagen, whereas galectin-1 was expressed from early anagen to late catagen. The ORS expressed galectin-3 binding sites during catagen transition corresponding to a galectin-3 expression during anagen V and catagen. The innermost layer of the ORS expressed galectin-3 binding sites during anagen VI until catagen VIII, but galectin-3 during anagen III to IV and catagen. The inner root sheath (IRS) expressed galectin-3 binding sites only in anagen IV but missed expression of any of the two galectins. The matrix cells expressed galectin-3 binding sites in catagen II-III as well as galectin-3 during anagen V to catagen IV. The present study provides the first evidence for a cycle-related expression of both galectin-1 and -3 and their binding sites during murine hair cycle.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalHistology and Histopathology
Volume15
Issue number1
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Galectin 1
Galectin 3
Hair
Binding Sites
Galectins
Skin Physiological Phenomena
Hair Follicle
Inbred C57BL Mouse
Lectins
Cell Adhesion

Keywords

  • Galectin-binding sites
  • Galectins
  • Hair cycle

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Expression of galectin-1 and -3 and of accessible binding sites during murine hair cycle. / Wollina, Uwe; Lange, D.; Paus, Ralf; Burchert, M.; Gabius, H. J.

In: Histology and Histopathology, Vol. 15, No. 1, 01.01.2000, p. 85-94.

Research output: Contribution to journalArticle

Wollina, U, Lange, D, Paus, R, Burchert, M & Gabius, HJ 2000, 'Expression of galectin-1 and -3 and of accessible binding sites during murine hair cycle', Histology and Histopathology, vol. 15, no. 1, pp. 85-94.
Wollina, Uwe ; Lange, D. ; Paus, Ralf ; Burchert, M. ; Gabius, H. J. / Expression of galectin-1 and -3 and of accessible binding sites during murine hair cycle. In: Histology and Histopathology. 2000 ; Vol. 15, No. 1. pp. 85-94.
@article{10b9de9c793245998396de2f4f3f5848,
title = "Expression of galectin-1 and -3 and of accessible binding sites during murine hair cycle",
abstract = "Although protein-carbohydrate interactions are supposed to play key roles in cell adhesion, signalling and growth control. Their exact role in skin physiology has only recently been investigated. The endogenous lectins galectin-1 and galectin-3 have been identified in skin including hair follicles. Here, we analyzed the expression and distribution of these galectins and their binding sites in C57BL/6 mice during hair cycle. The expression of galectin-1 and galectin-3 binding sites was found to be predominantly hair cycle-dependent showing some overlapping to the expression of galectin-1 and -3. The outer root sheath (ORS) expressed galectin-1 binding sites during anagen IV to VI and in early catagen, whereas galectin-1 was expressed from early anagen to late catagen. The ORS expressed galectin-3 binding sites during catagen transition corresponding to a galectin-3 expression during anagen V and catagen. The innermost layer of the ORS expressed galectin-3 binding sites during anagen VI until catagen VIII, but galectin-3 during anagen III to IV and catagen. The inner root sheath (IRS) expressed galectin-3 binding sites only in anagen IV but missed expression of any of the two galectins. The matrix cells expressed galectin-3 binding sites in catagen II-III as well as galectin-3 during anagen V to catagen IV. The present study provides the first evidence for a cycle-related expression of both galectin-1 and -3 and their binding sites during murine hair cycle.",
keywords = "Galectin-binding sites, Galectins, Hair cycle",
author = "Uwe Wollina and D. Lange and Ralf Paus and M. Burchert and Gabius, {H. J.}",
year = "2000",
month = "1",
day = "1",
language = "English (US)",
volume = "15",
pages = "85--94",
journal = "Histology and Histopathology",
issn = "0213-3911",
publisher = "Histology and Histopathology",
number = "1",

}

TY - JOUR

T1 - Expression of galectin-1 and -3 and of accessible binding sites during murine hair cycle

AU - Wollina, Uwe

AU - Lange, D.

AU - Paus, Ralf

AU - Burchert, M.

AU - Gabius, H. J.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Although protein-carbohydrate interactions are supposed to play key roles in cell adhesion, signalling and growth control. Their exact role in skin physiology has only recently been investigated. The endogenous lectins galectin-1 and galectin-3 have been identified in skin including hair follicles. Here, we analyzed the expression and distribution of these galectins and their binding sites in C57BL/6 mice during hair cycle. The expression of galectin-1 and galectin-3 binding sites was found to be predominantly hair cycle-dependent showing some overlapping to the expression of galectin-1 and -3. The outer root sheath (ORS) expressed galectin-1 binding sites during anagen IV to VI and in early catagen, whereas galectin-1 was expressed from early anagen to late catagen. The ORS expressed galectin-3 binding sites during catagen transition corresponding to a galectin-3 expression during anagen V and catagen. The innermost layer of the ORS expressed galectin-3 binding sites during anagen VI until catagen VIII, but galectin-3 during anagen III to IV and catagen. The inner root sheath (IRS) expressed galectin-3 binding sites only in anagen IV but missed expression of any of the two galectins. The matrix cells expressed galectin-3 binding sites in catagen II-III as well as galectin-3 during anagen V to catagen IV. The present study provides the first evidence for a cycle-related expression of both galectin-1 and -3 and their binding sites during murine hair cycle.

AB - Although protein-carbohydrate interactions are supposed to play key roles in cell adhesion, signalling and growth control. Their exact role in skin physiology has only recently been investigated. The endogenous lectins galectin-1 and galectin-3 have been identified in skin including hair follicles. Here, we analyzed the expression and distribution of these galectins and their binding sites in C57BL/6 mice during hair cycle. The expression of galectin-1 and galectin-3 binding sites was found to be predominantly hair cycle-dependent showing some overlapping to the expression of galectin-1 and -3. The outer root sheath (ORS) expressed galectin-1 binding sites during anagen IV to VI and in early catagen, whereas galectin-1 was expressed from early anagen to late catagen. The ORS expressed galectin-3 binding sites during catagen transition corresponding to a galectin-3 expression during anagen V and catagen. The innermost layer of the ORS expressed galectin-3 binding sites during anagen VI until catagen VIII, but galectin-3 during anagen III to IV and catagen. The inner root sheath (IRS) expressed galectin-3 binding sites only in anagen IV but missed expression of any of the two galectins. The matrix cells expressed galectin-3 binding sites in catagen II-III as well as galectin-3 during anagen V to catagen IV. The present study provides the first evidence for a cycle-related expression of both galectin-1 and -3 and their binding sites during murine hair cycle.

KW - Galectin-binding sites

KW - Galectins

KW - Hair cycle

UR - http://www.scopus.com/inward/record.url?scp=0033963351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033963351&partnerID=8YFLogxK

M3 - Article

C2 - 10668199

AN - SCOPUS:0033963351

VL - 15

SP - 85

EP - 94

JO - Histology and Histopathology

JF - Histology and Histopathology

SN - 0213-3911

IS - 1

ER -