Abstract
Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the expression of the cannabinoid CB1 receptor mRNA in post-mortem brain tissue obtained from normal subjects and patients dying with Parkinson's disease. CB1 receptor mRNA was detected in striatal (nucleus accumbens, caudate nucleus and putamen) and extrastriatal (globus pallidus, substantia nigra) brain regions. In parkinsonian tissue the level of CB1 receptor mRNA was decreased in the caudate nucleus, anterior dorsal putamen and external segment of the globus pallidus, but remained unchanged in the other brain areas examined. These results show that CB 1 receptor mRNA expression was altered in Parkinson's disease (though the effects of drug treatment can not be ruled out) and indicate that cannabinoid CB1 receptor mRNA expression was affected by alterations in dopaminergic systems.
| Original language | English |
|---|---|
| Pages (from-to) | 1279-1288 |
| Number of pages | 10 |
| Journal | Journal of Neural Transmission |
| Volume | 110 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2003 |
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Keywords
- Basal ganglia
- Cannabinoid CB
- Parkinson's disease
- Receptor mRNA
- RT-PCR
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain. / Hurley, M. J.; Mash, Deborah C; Jenner, P.
In: Journal of Neural Transmission, Vol. 110, No. 11, 01.11.2003, p. 1279-1288.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of cannabinoid CB1 receptor mRNA in basal ganglia of normal and parkinsonian human brain
AU - Hurley, M. J.
AU - Mash, Deborah C
AU - Jenner, P.
PY - 2003/11/1
Y1 - 2003/11/1
N2 - Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the expression of the cannabinoid CB1 receptor mRNA in post-mortem brain tissue obtained from normal subjects and patients dying with Parkinson's disease. CB1 receptor mRNA was detected in striatal (nucleus accumbens, caudate nucleus and putamen) and extrastriatal (globus pallidus, substantia nigra) brain regions. In parkinsonian tissue the level of CB1 receptor mRNA was decreased in the caudate nucleus, anterior dorsal putamen and external segment of the globus pallidus, but remained unchanged in the other brain areas examined. These results show that CB 1 receptor mRNA expression was altered in Parkinson's disease (though the effects of drug treatment can not be ruled out) and indicate that cannabinoid CB1 receptor mRNA expression was affected by alterations in dopaminergic systems.
AB - Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the expression of the cannabinoid CB1 receptor mRNA in post-mortem brain tissue obtained from normal subjects and patients dying with Parkinson's disease. CB1 receptor mRNA was detected in striatal (nucleus accumbens, caudate nucleus and putamen) and extrastriatal (globus pallidus, substantia nigra) brain regions. In parkinsonian tissue the level of CB1 receptor mRNA was decreased in the caudate nucleus, anterior dorsal putamen and external segment of the globus pallidus, but remained unchanged in the other brain areas examined. These results show that CB 1 receptor mRNA expression was altered in Parkinson's disease (though the effects of drug treatment can not be ruled out) and indicate that cannabinoid CB1 receptor mRNA expression was affected by alterations in dopaminergic systems.
KW - Basal ganglia
KW - Cannabinoid CB
KW - Parkinson's disease
KW - Receptor mRNA
KW - RT-PCR
UR - http://www.scopus.com/inward/record.url?scp=0345490815&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345490815&partnerID=8YFLogxK
U2 - 10.1007/s00702-003-0033-7
DO - 10.1007/s00702-003-0033-7
M3 - Article
C2 - 14628192
AN - SCOPUS:0345490815
VL - 110
SP - 1279
EP - 1288
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 11
ER -