Expression of a functional secreted YopN-TyeA hybrid protein in Yersinia pestis is the result of a +1 translational frameshift event

Franco Ferracci; James B. Day; Heather J. Ezelle; Gregory V. Plano

doi:10.1128/JB.186.15.5160-5166.2004

Expression of a functional secreted YopN-TyeA hybrid protein in Yersinia pestis is the result of a +1 translational frameshift event

Franco Ferracci, James B. Day, Heather J. Ezelle, Gregory V. Plano

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

YopN is a secreted protein that prior to secretion directly interacts with the cytosolic SycN/YscB chaperone complex and TyeA. This study identifies a secreted YopN-TyeA hybrid protein that is expressed by Yersinia pestis, but not by Yersinia enterocolitica. DNA sequence analysis and site-directed mutagenesis studies demonstrate that the hybrid protein is the result of a +1 translational frameshift event.

Original language	English (US)
Pages (from-to)	5160-5166
Number of pages	7
Journal	Journal of bacteriology
Volume	186
Issue number	15
DOIs	https://doi.org/10.1128/JB.186.15.5160-5166.2004
State	Published - Aug 2004

ASJC Scopus subject areas

Microbiology
Molecular Biology

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AU - Ezelle, Heather J.

AU - Plano, Gregory V.

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AB - YopN is a secreted protein that prior to secretion directly interacts with the cytosolic SycN/YscB chaperone complex and TyeA. This study identifies a secreted YopN-TyeA hybrid protein that is expressed by Yersinia pestis, but not by Yersinia enterocolitica. DNA sequence analysis and site-directed mutagenesis studies demonstrate that the hybrid protein is the result of a +1 translational frameshift event.

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Expression of a functional secreted YopN-TyeA hybrid protein in Yersinia pestis is the result of a +1 translational frameshift event

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