Expression of a functional secreted YopN-TyeA hybrid protein in Yersinia pestis is the result of a +1 translational frameshift event

Franco Ferracci, James B. Day, Heather J. Ezelle, Gregory V. Plano

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

YopN is a secreted protein that prior to secretion directly interacts with the cytosolic SycN/YscB chaperone complex and TyeA. This study identifies a secreted YopN-TyeA hybrid protein that is expressed by Yersinia pestis, but not by Yersinia enterocolitica. DNA sequence analysis and site-directed mutagenesis studies demonstrate that the hybrid protein is the result of a +1 translational frameshift event.

Original languageEnglish (US)
Pages (from-to)5160-5166
Number of pages7
JournalJournal of bacteriology
Volume186
Issue number15
DOIs
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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